Ragonese Paolo, D'Amelio Marco, Callari Graziella, Aiello Fabio, Morgante Letterio, Savettieri Giovanni
Dipartimento Universitario di Neuroscienze Cliniche, Università di Palermo, Palermo, Italy.
Mov Disord. 2007 Nov 15;22(15):2263-7. doi: 10.1002/mds.21728.
Aim of this study was to investigate the relationship between height in young adult age and Parkinson's disease (PD) risk. We included 266 persons affected by idiopathic PD. Patients were matched by age and sex to 266 controls by a random selection from the municipality of residence. We collected information about height preceding PD from official documents where these characteristics referred to young adult age (nearly 30 years). We compared height in cases and controls by calculating differences in mean distribution and by chi(2) analyses. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression models. Mean height was significantly lower in persons affected by PD compared to controls (P = 0.03). Difference was significant only in men (P = 0.001). Logistic regression models showed an inverse association between height and PD (OR 0.35; CI 0.16, 0.79; P < 0.01 comparing individuals in the highest percentiles of height with those in the lowest). Our results indicate an association between height and PD in men. Considering that dopamine sensitivity in the hypothalamic-pituitary axis is related to adult height, our findings suggest a relationship between PD and factors modulating somatic growth early in life.
本研究的目的是调查青年时期的身高与帕金森病（PD）风险之间的关系。我们纳入了266例特发性帕金森病患者。通过从居住城市随机选取的方式，将患者按年龄和性别与266名对照进行匹配。我们从官方文件中收集了帕金森病发病前与青年时期（近30岁）相关的身高信息。我们通过计算平均分布差异和卡方分析来比较病例组和对照组的身高。通过逻辑回归模型计算粗比值比（OR）和调整后的比值比以及95%置信区间（CI）。与对照组相比，帕金森病患者的平均身高显著较低（P = 0.03）。差异仅在男性中显著（P = 0.001）。逻辑回归模型显示身高与帕金森病之间存在负相关（OR 0.35；CI 0.16, 0.79；将身高最高百分位数的个体与最低百分位数的个体进行比较，P < 0.01）。我们的结果表明男性身高与帕金森病之间存在关联。考虑到下丘脑 - 垂体轴中的多巴胺敏感性与成年身高有关，我们的研究结果提示帕金森病与生命早期调节身体生长的因素之间存在关系。
