铱催化的区域和对映选择性脱羧烯丙基烷基化反应
Ir-catalyzed regio- and enantioselective decarboxylative allylic alkylations.
作者信息
He Hu, Zheng Xiao-Jian, Li Yi, Dai Li-Xin, You Shu-Li
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
出版信息
Org Lett. 2007 Oct 11;9(21):4339-41. doi: 10.1021/ol7019394. Epub 2007 Sep 14.
PMID:17854201
Abstract
[Ir(COD)Cl]2/phosphoramidite ligand 1a was found to be an efficient catalytic system for the highly regio- and enantioselective decarboxylative alkylation of gamma-substituted allyl beta-ketocarboxylates, affording the branched products with up to >99/1 branched-linear ratio and 96% ee.
摘要
发现[Ir(COD)Cl]2/亚磷酰胺配体1a是一种高效的催化体系，可用于γ-取代烯丙基β-酮羧酸盐的高度区域和对映选择性脱羧烷基化反应，得到支链产物，支链与直链比例高达>99/1，对映体过量值为96%。
Zotero 插件