Double-stranded DNA-templated oligonucleotide digestion triggered by triplex formation. - Suppr | 超能文献

Double-stranded DNA-templated oligonucleotide digestion triggered by triplex formation.

作者信息

Obika Satoshi, Tomizu Masaharu, Negoro Yoshinori, Orita Ayako, Nakagawa Osamu, Imanishi Takeshi

机构信息

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

出版信息

Chembiochem. 2007 Nov 5;8(16):1924-8. doi: 10.1002/cbic.200700430.

DOI:10.1002/cbic.200700430

Abstract

摘要

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Double-stranded DNA-templated cleavage of oligonucleotides containing a P3'->N5' linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity.双链 DNA 模板引导的寡核苷酸断裂，其中包含 P3'->N5' 键，由三链体形成触发：化学修饰的影响和反应性的显著增强。

Nucleic Acids Res. 2010 Nov;38(20):7332-42. doi: 10.1093/nar/gkq600. Epub 2010 Jul 8.