用于治疗性新生血管形成的生长因子信号传导的时空控制。
Spatiotemporal control over growth factor signaling for therapeutic neovascularization.
作者信息
Cao Lan, Mooney David J
机构信息
School of Engineering and Applied Science, Harvard University, Cambridge, MA, 02138, USA.
出版信息
Adv Drug Deliv Rev. 2007 Nov 10;59(13):1340-50. doi: 10.1016/j.addr.2007.08.012. Epub 2007 Aug 16.
Abstract
Many of the qualitative roles of growth factors involved in neovascularization have been delineated, but it is unclear yet from an engineering perspective how to use these factors as therapies. We propose that an approach that integrates quantitative spatiotemporal measurements of growth factor signaling using 3-D in vitro and in vivo models, mathematic modeling of factor tissue distribution, and new delivery technologies may provide an opportunity to engineer neovascularization on demand.
摘要
参与新血管形成的生长因子的许多定性作用已被阐明，但从工程学角度来看，尚不清楚如何将这些因子用作治疗手段。我们提出，一种将使用三维体外和体内模型对生长因子信号进行定量时空测量、因子组织分布的数学建模以及新的递送技术相结合的方法，可能会提供按需构建新血管形成的机会。
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