来自毛韧革菌的新型生物活性环氧甾醇。

New biologically active epidioxysterols from Stereum hirsutum.

作者信息

Cateni Francesca, Doljak Bojan, Zacchigna Marina, Anderluh Marko, Piltaver Andrej, Scialino Giuditta, Banfi Elena

机构信息

Department of Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, Trieste, Italy.

出版信息

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6330-4. doi: 10.1016/j.bmcl.2007.08.072. Epub 2007 Sep 2.

DOI:10.1016/j.bmcl.2007.08.072

PMID:17869507

Abstract

From the fungus Stereum hirsutum have been isolated and identified two new epidioxysterols 1, 4, together with two known ones 2 and 3. Their structures were elucidated on the basis of spectroscopic analysis and chemical reactions. Epidioxysterols 1-4 have been shown to possess a significant activity against Mycobacterium tuberculosis.

摘要

从真菌毛革盖菌中分离并鉴定出两种新的表二氧甾醇1、4，以及两种已知的表二氧甾醇2和3。基于光谱分析和化学反应阐明了它们的结构。已表明表二氧甾醇1 - 4对结核分枝杆菌具有显著活性。