Burkhart Craig G, Burkhart Craig N
University of Toledo School of Medicine, Sylvania, Ohio, USA.
J Am Acad Dermatol. 2007 Oct;57(4):722-4. doi: 10.1016/j.jaad.2007.05.013.
The Propionibacterium acnes biofilm has previously been shown to exist via genomic studies and to make a biological glue which allows for adherence to follicular walls. This gylcocalyx polymer secreted by P acnes also finds its way into sebum composition where it causes the adhesiveness of keratinocytes leading to comedones. An appreciation of P acnes biofilms and secretions has implications in immunogenicity of the organism, clinical course of acne, and therapy for comedonal and inflammatory acne.
痤疮丙酸杆菌生物膜先前已通过基因组研究证实存在，并能产生一种生物胶水，使其能够附着在毛囊壁上。痤疮丙酸杆菌分泌的这种糖萼聚合物也会进入皮脂成分中，导致角质形成细胞黏附，进而形成粉刺。了解痤疮丙酸杆菌生物膜及其分泌物对该生物体的免疫原性、痤疮的临床病程以及粉刺性和炎性痤疮的治疗具有重要意义。
