Wigand R, Bruch P, Heckenhahn K
Klin Monbl Augenheilkd. 1975 Dec;167(6):823-9.
In 93 patients (mostly sporadic cases) with suspected EKC an infection with adenoviruses was proved by virological and serological methods in 54 cases. Types 8, 3, 7, 19, 4, and 14 were found in 38, 6, 5, 3, 1, and 1 cases respectively. 33 out of 48 patients with clinically typical EKC had an infection with type 8. From the patients without adenoviral infection, the absence of which having been proved by extensive serological tests, 7 showed a typical EKC. The symptoms considered as relatively typical (hyperemia and oedema of the plica and caruncle, subepithelial corneal infiltrates) were not confined to patients with adenovirus infection; thus they cannot be considered as characteristic for this group of viruses. The results indicate the need for a specific diagnosis in cases of suspected EKC, which should include virus isolation from conjunctival swabs as well as the demonstration of antibody titer rises by various serological tests. EKC is to be considered as a clinical and epidemiological rather than as an etiological entity.
在93例疑似流行性角结膜炎(EKC)的患者(大多为散发病例)中,通过病毒学和血清学方法证实54例感染了腺病毒。分别在38、6、5、3、1和1例中发现了8型、3型、7型、19型、4型和14型。48例临床典型EKC患者中有33例感染了8型。在经广泛血清学检测证实无腺病毒感染的患者中,7例表现出典型的EKC。被认为相对典型的症状(睑褶和泪阜充血、水肿,角膜上皮下浸润)并不局限于腺病毒感染患者;因此,不能将它们视为该组病毒的特征性表现。结果表明,对于疑似EKC病例需要进行特异性诊断,这应包括从结膜拭子中分离病毒以及通过各种血清学检测证明抗体滴度升高。EKC应被视为一种临床和流行病学实体,而非病因学实体。