Vandenplas Yvan, Koletzko Sibylle, Isolauri Erika, Hill David, Oranje Arnold P, Brueton Martin, Staiano Annamaria, Dupont Christophe
Department of Paediatrics, Universitair Ziekenhuis Brussel Kinderen, Vrije Universiteit Brussel, Brussels, Belgium.
Arch Dis Child. 2007 Oct;92(10):902-8. doi: 10.1136/adc.2006.110999.
Our aim was to develop guidance for general paediatricians and primary care physicians in diagnosing and managing cow's milk protein allergy in infants. The guidelines were developed by discussion based on existing national recommendations and standards, clinical experience and, whenever possible, evidence from the literature. Separate algorithms cover breast-fed and formula-fed infants. The recommendations emphasise the importance of comprehensive history taking and careful physical examination. Patients with severe symptoms need to be referred to a specialist. Elimination of cow's milk protein from the infant's or mother's diet and challenges are the gold standard for diagnosis. This guidance is intended as a basis for local discussion, implementation and prospective evaluation. The algorithms should be regularly assessed using clinical audit standards. Once validated, the diagnostic framework could provide a standardised approach in epidemiological and therapeutic studies.
我们的目标是为普通儿科医生和初级保健医生制定有关诊断和管理婴儿牛奶蛋白过敏的指南。这些指南是在现有国家建议和标准、临床经验以及尽可能参考文献证据的基础上，通过讨论制定的。单独的算法涵盖母乳喂养和配方奶喂养的婴儿。这些建议强调了全面病史采集和仔细体格检查的重要性。有严重症状的患者需要转诊给专科医生。从婴儿或母亲的饮食中去除牛奶蛋白并进行激发试验是诊断的金标准。本指南旨在作为地方讨论、实施和前瞻性评估的基础。应使用临床审计标准定期评估这些算法。一旦经过验证，该诊断框架可为流行病学和治疗研究提供标准化方法。
