Rice Suman, Whitehead Saffron A
Division of Basic Medical Sciences, St. George's University of London, Cranmer Terrace, London, United Kingdom.
J Steroid Biochem Mol Biol. 2008 Feb;108(3-5):186-95. doi: 10.1016/j.jsbmb.2007.09.003. Epub 2007 Sep 7.
Phytoestrogens are used as 'natural' alternatives to HRT and, although epidemiological evidence implies that diets rich in phytoestrogens reduce the incidence of breast cancer, their weak oestrogenicity is also known to stimulate growth in experimental models of breast cancer. This review addresses the question as to how phytoestrogens may protect against breast cancer through their ability to bind preferentially to oestrogen receptor beta, inhibit enzymes that convert circulating steroid precursors into oestradiol and inhibit cell signalling pathways of growth factors.
植物雌激素被用作激素替代疗法（HRT）的“天然”替代品，尽管流行病学证据表明富含植物雌激素的饮食可降低乳腺癌的发病率，但众所周知，其微弱的雌激素活性也会在乳腺癌实验模型中刺激生长。本综述探讨了植物雌激素如何通过优先结合雌激素受体β、抑制将循环类固醇前体转化为雌二醇的酶以及抑制生长因子的细胞信号通路来预防乳腺癌这一问题。
