Potthoff Anja, Brockmeyer Norbert H
Department of Dermatology and Allergy, St. Josef Hospital, Ruhr-University Bochum, Germany.
J Dtsch Dermatol Ges. 2007 Dec;5(12):1091-4. doi: 10.1111/j.1610-0387.2007.06567.x. Epub 2007 Oct 18.
While classical Kaposi sarcoma is a slowly progressing tumor, AIDS-related Kaposi sarcoma is much more aggressive. After introduction of antiretroviral therapy and with the use of well- tolerated chemotherapeutic agents, complete remission of the tumor can be achieved. Local therapeutic options include excision, cryosurgery, radiation and alitretinoin gel. In 45 % of patients with more than 400/microl CD4+ lymphocytes, interferon-alpha induces complete remission. New concepts of pathogenesis lead to therapeutic targets, such as inhibition of angiogenesis.
虽然经典型卡波西肉瘤是一种进展缓慢的肿瘤，但艾滋病相关的卡波西肉瘤侵袭性更强。在引入抗逆转录病毒疗法并使用耐受性良好的化疗药物后，肿瘤可实现完全缓解。局部治疗选择包括切除、冷冻手术、放疗和阿利维A酸凝胶。在CD4 +淋巴细胞计数超过400/微升的患者中，45%的患者使用α干扰素可实现完全缓解。发病机制的新概念带来了治疗靶点，如抑制血管生成。
