Ramagopalan S V, Ramscar N E, Cader M Z
Dept. of Clinical Neurology, University of Oxford, Oxford, UK.
J Neurol. 2007 Dec;254(12):1629-35. doi: 10.1007/s00415-007-0641-5. Epub 2007 Nov 7.
Migraine is a common debilitating neurological disease characterised by attacks of severe headache with or without preceding aura. Its aetiology remains elusive; however it is clear that an interplay of genetic and environmental components play an important role. Familial hemiplegic migraine (FHM) is a rare and severe variant of migraine with aura and follows an autosomal dominant pattern of inheritance. This disease is genetically heterogeneous,with three causative genes having been identified. This review uses insights garnered from FHM to try and shed light on possible migraine disease pathogenesis.
偏头痛是一种常见的使人衰弱的神经疾病，其特征为发作性重度头痛，可伴有或不伴有前驱先兆。其病因尚不清楚；然而，很明显，遗传因素和环境因素的相互作用起着重要作用。家族性偏瘫性偏头痛（FHM）是偏头痛伴先兆的一种罕见且严重的类型，呈常染色体显性遗传模式。这种疾病在遗传上具有异质性，已确定了三个致病基因。本综述利用从FHM中获得的见解，试图阐明偏头痛疾病可能的发病机制。
