细胞色素P3A4抑制剂及锡生藤的其他成分。
Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria.
作者信息
Su Chung-Ren, Ueng Yune-Fang, Dung Nguyen Xuan, Vijaya Bhaskar Reddy M, Wu Tian-Shung
机构信息
Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, ROC.
出版信息
J Nat Prod. 2007 Dec;70(12):1930-3. doi: 10.1021/np0704248. Epub 2007 Nov 10.
Four new furanoditerpenoids, fibrauretin A ( 1), fibrauretinoside A ( 2), epi-fibrauretinoside A ( 3), and epi-12-palmatoside G ( 4), and a new ecdysteroid glucoside, fibraurecdyside A ( 5), together with seven known compounds including two furanoditerpenoids ( 6 and 7), an ecdysteroid ( 8), and four quaternary protoberberine alkaloids ( 9- 12) were isolated from the stems of Fibraurea tinctoria. The structures of 1- 5 were established on the basis of spectroscopic evidence. Among these compounds, palmatine ( 9) and jatrorrhizine ( 10) showed inhibitory effects against cytochrome P450 3A4 (CYP3A4) with IC 50 values of 0.9 and 2.1 microM, respectively.
从黄藤茎中分离得到4个新的呋喃二萜类化合物，黄藤素A（1）、黄藤苷A（2）、表黄藤苷A（3）和表12-掌叶苷G（4），以及1个新的蜕皮甾类糖苷，黄藤蜕皮苷A（5），同时还得到7个已知化合物，包括2个呋喃二萜类化合物（6和7）、1个蜕皮甾类化合物（8）和4个季铵型原小檗碱生物碱（9 - 12）。通过光谱数据确定了化合物1 - 5的结构。在这些化合物中，巴马汀（9）和药根碱（10）对细胞色素P450 3A4（CYP3A4）具有抑制作用，IC50值分别为0.9和2.1微摩尔。
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