Torrent C, Martínez-Arán A, Amann B, Daban C, Tabarés-Seisdedos R, González-Pinto A, Reinares M, Benabarre A, Salamero M, McKenna P, Vieta E
Bipolar Disorder Program, Clinical Institute of Neuroscience, University Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain.
Acta Psychiatr Scand. 2007 Dec;116(6):453-60. doi: 10.1111/j.1600-0447.2007.01072.x.
Only a few studies have examined specifically the neuropsychological performance of schizoaffective patients.
The sample consisted of 34 euthymic DSM-IV schizoaffective patients, who were compared with 41 euthymic bipolar patients without history of psychotic symptoms and 35 healthy controls. Euthymia was defined by a score of 6 or less at the Young Mania Rating Scale and a score of 8 or less at the Hamilton Depression Rating Scale for at least 6 months. Patients were compared with several clinical, occupational, and neuropsychological variables such as executive function, attention, verbal and visual memory and the two groups were contrasted with 35 healthy controls on cognitive performance. The three groups were compared using mancova after checking the potential role of several co-variables.
Schizoaffective patients showed greater impairment than controls and bipolar patients, in several domains, including verbal memory, executive function, and attentional measures. Bipolar patients without history of psychosis performed similar to the controls except for verbal fluency.
Schizoaffective disorder carries more neurocognitive impairment than non-psychotic bipolar disorder and more occupational difficulties.
仅有少数研究专门考察了分裂情感性障碍患者的神经心理学表现。
样本包括34名处于心境正常期的DSM-IV分裂情感性障碍患者，将他们与41名无精神病症状病史的心境正常的双相情感障碍患者以及35名健康对照者进行比较。心境正常的定义为，杨氏躁狂评定量表得分6分及以下，汉密尔顿抑郁评定量表得分8分及以下，且持续至少6个月。对患者与若干临床、职业和神经心理学变量进行比较，如执行功能、注意力、言语和视觉记忆，并将这两组患者与35名健康对照者在认知表现方面进行对比。在检查了若干协变量的潜在作用后，使用多变量协方差分析对三组进行比较。
在包括言语记忆、执行功能和注意力测量等多个领域，分裂情感性障碍患者比对照者和双相情感障碍患者表现出更严重的损害。无精神病症状病史的双相情感障碍患者除言语流畅性外，表现与对照者相似。
分裂情感性障碍比非精神病性双相情感障碍具有更多的神经认知损害和更多的职业困难。
