Jayasuriya H, Clark A M, McChesney J D
Department of Pharmacognosy, University of Mississippi, University 38677.
J Nat Prod. 1991 Sep-Oct;54(5):1314-20. doi: 10.1021/np50077a013.
Bioactivity-guided fractionation of the hexane extract of the stems and leaves of Hypericum drummondii has afforded four new filicinic acid derivatives: drummondin D, isodrummondin D, drummondin E, and drummondin F. The structures of these compounds were established by spectroscopic methods. All compounds possessed strong antibiotic activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and the acid fast bacterium Mycobacterium smegmatis.
对金丝桃属植物川金丝桃茎叶的己烷提取物进行生物活性导向分离，得到了四种新的绵马酸衍生物：川金丝桃素D、异川金丝桃素D、川金丝桃素E和川金丝桃素F。这些化合物的结构通过光谱方法确定。所有化合物对革兰氏阳性菌金黄色葡萄球菌和枯草芽孢杆菌以及抗酸菌耻垢分枝杆菌均具有较强的抗菌活性。
