Jayasuriya H, McChesney J D, Swanson S M, Pezzuto J M
Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University 38677.
J Nat Prod. 1989 Mar-Apr;52(2):325-31. doi: 10.1021/np50062a018.
Hexane extracts of Hypericum drummondii showed significant activity against the Gram-positive bacteria Staphylococcus aureus, Bacillus subtilis, and the acid-fast bacterium Mycobacterium smegmatis in an agar well diffusion assay. Employing bioassay-directed fractionation procedures, four new rottlerin-type compounds (drummondins A, B, C[1-3], and F [4]) were isolated and identified by spectral and physical characterization. The antimicrobial activity of these compounds was comparable to or greater than that demonstrated by streptomycin and generally correlated with cytotoxic activity determined with cultured P-388, KB, or human cancer cell lines (breast, colon, lung, melanoma). No cell-type selectivity was observed. In addition, two known compounds, albaspidins A-A [5] and P-P [6], were isolated and structured characterized. Neither demonstrated appreciable antimicrobial or cytotoxic activity.
在琼脂孔扩散试验中，金丝桃属植物德拉蒙德金丝桃的己烷提取物对革兰氏阳性菌金黄色葡萄球菌、枯草芽孢杆菌以及抗酸菌耻垢分枝杆菌显示出显著活性。采用生物活性导向的分级分离程序，通过光谱和物理表征分离并鉴定出四种新的鱼藤酮型化合物（德拉蒙德素A、B、C[1-3]和F[4]）。这些化合物的抗菌活性与链霉素相当或更强，并且通常与用培养的P-388、KB或人类癌细胞系（乳腺癌、结肠癌、肺癌、黑色素瘤）测定的细胞毒性活性相关。未观察到细胞类型选择性。此外，还分离出两种已知化合物，阿尔巴斯皮定A-A[5]和P-P[6]，并对其结构进行了表征。两者均未表现出明显的抗菌或细胞毒性活性。
