Robinson Lindsay E, Buchholz Andrea C, Mazurak Vera C
Department of Human Health and Nutritional Sciences, Room 336-B Animal Science and Nutrition Building, University of Guelph, Guelph, ON N1G 2W1, Canada.
Appl Physiol Nutr Metab. 2007 Dec;32(6):1008-24. doi: 10.1139/H07-087.
Metabolic syndrome (MetS) comprises an array of metabolic risk factors including abdominal obesity, dyslipidemia, hypertension, and glucose intolerance. Individuals with MetS are at elevated risk for diabetes and cardiovascular disease. Central to the etiology of MetS is an interrelated triad comprising inflammation, abdominal obesity, and aberrations in fatty acid metabolism, coupled with the more recently recognized changes in metabolism during the postprandial period. We review herein preliminary evidence regarding the role of dietary n-3 polyunsaturated fatty acids in modulating each of the components of the triad of adiposity, inflammation, and fatty acid metabolism, with particular attention to the role of the postprandial period as a contributor to the pathophysiology of MetS.
代谢综合征（MetS）包括一系列代谢风险因素，如腹型肥胖、血脂异常、高血压和糖耐量异常。患有代谢综合征的个体患糖尿病和心血管疾病的风险较高。代谢综合征病因的核心是一个相互关联的三联征，包括炎症、腹型肥胖和脂肪酸代谢异常，以及最近认识到的餐后代谢变化。本文综述了关于膳食n-3多不饱和脂肪酸在调节肥胖、炎症和脂肪酸代谢三联征各组成部分中的作用的初步证据，特别关注餐后时期作为代谢综合征病理生理学促成因素的作用。
