Liu Je-Ruei, Chen Guo-Feng, Shih Hui-Nung, Kuo Ping-Chung
Department of Animal Science and Technology and Institute of Biotechnology, National Taiwan University, Taipei 102, Taiwan, ROC.
Phytomedicine. 2008 Jan;15(1-2):23-30. doi: 10.1016/j.phymed.2007.11.012.
The traditional Chinese medicine, Salvia miltiorrhiza (Danshen), promotes blood circulation and relieves blood stasis, also demonstrating good antioxidant activity. In the present study, therefore, the antioxidant activities of medicinal plant materials prepared using nanotechnology or traditional grinding methods were compared using three biological assays. It was found that the nanotechnology preparation had stronger antioxidant bioactivities. Complementary quantitative analysis of four active constituents, salvianolic acid B, cryptotanshinone, tanshinone I and tanshinone IIA, by HPLC revealed only marked differences for salvianolic acid B. The results indicate that the polar active constituent in the nanotechnology samples was released faster compared to the traditionally powdered samples.
传统中药丹参具有活血化瘀的功效，还表现出良好的抗氧化活性。因此，在本研究中，使用三种生物学测定方法比较了采用纳米技术或传统研磨方法制备的药用植物材料的抗氧化活性。结果发现，纳米技术制备的材料具有更强的抗氧化生物活性。通过高效液相色谱法对丹酚酸B、隐丹参酮、丹参酮I和丹参酮IIA这四种活性成分进行的补充定量分析表明，仅丹酚酸B存在显著差异。结果表明，与传统粉末状样品相比，纳米技术样品中的极性活性成分释放得更快。
