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本文引用的文献

1
Mycobacterium avium subspecies paratuberculosis bacteremia in type 1 diabetes mellitus: an infectious trigger?1型糖尿病中的副结核分枝杆菌鸟型亚种菌血症：一种感染触发因素？
Clin Infect Dis. 2008 Jan 1;46(1):148-9. doi: 10.1086/524084.
2
Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression.结核DNA疫苗诱导的免疫调节可保护非肥胖糖尿病小鼠免于糖尿病进展。
Clin Exp Immunol. 2007 Sep;149(3):570-8. doi: 10.1111/j.1365-2249.2007.03433.x. Epub 2007 Jun 22.
3
Autoreactive antibodies are present in sheep with Johne's disease and cross-react with Mycobacterium avium subsp. paratuberculosis antigens.自身反应性抗体存在于患有副结核病的绵羊体内，并与鸟分枝杆菌副结核亚种抗原发生交叉反应。
Microbes Infect. 2007 Jul;9(8):963-70. doi: 10.1016/j.micinf.2007.03.016. Epub 2007 Apr 7.
4
Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients.撒丁岛患者中克罗恩病、副结核分枝杆菌感染与SLC11A1基因多态性之间的关系
World J Gastroenterol. 2006 Nov 28;12(44):7161-4. doi: 10.3748/wjg.v12.i44.7161.
5
Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease?鸟分枝杆菌副结核分枝杆菌与人类肠道抗原之间的交叉反应是否是克罗恩病的特征？
Gastroenterology. 2006 Jul;131(1):85-96. doi: 10.1053/j.gastro.2006.04.021.
6
Paratuberculosis and Type I diabetes: is this the trigger?副结核病与1型糖尿病：这是诱因吗？
Med Hypotheses. 2006;67(4):782-5. doi: 10.1016/j.mehy.2006.04.029. Epub 2006 Jul 7.
7
Mycobacterium avium subsp. paratuberculosis in lake catchments, in river water abstracted for domestic use, and in effluent from domestic sewage treatment works: diverse opportunities for environmental cycling and human exposure.湖泊集水区、抽取用于家庭用水的河水中以及生活污水处理厂的废水中的副结核分枝杆菌：环境循环和人类接触的多种机会。
Appl Environ Microbiol. 2006 Jun;72(6):4067-77. doi: 10.1128/AEM.02490-05.
8
Mechanisms of disease: the hygiene hypothesis revisited.疾病机制：重新审视卫生假说
Nat Clin Pract Gastroenterol Hepatol. 2006 May;3(5):275-84. doi: 10.1038/ncpgasthep0471.
9
Mycobacterium avium ssp. paratuberculosis and its potential survival tactics.副结核分枝杆菌及其潜在的生存策略。
Lett Appl Microbiol. 2006 Apr;42(4):305-11. doi: 10.1111/j.1472-765X.2006.01873.x.
10
In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.体内RNA干扰表明Nramp1在改变1型糖尿病易感性方面发挥作用。
Nat Genet. 2006 Apr;38(4):479-83. doi: 10.1038/ng1766. Epub 2006 Mar 19.

1型糖尿病患者对副结核分枝杆菌的体液免疫反应支持感染触发假说。

Humoral immune responses of type 1 diabetes patients to Mycobacterium avium subsp. paratuberculosis lend support to the infectious trigger hypothesis.

作者信息

Sechi Leonardo A, Rosu Valentina, Pacifico Adolfo, Fadda Giovanni, Ahmed Niyaz, Zanetti Stefania

机构信息

Dipartimento di Scienze Biomediche, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.

出版信息

Clin Vaccine Immunol. 2008 Feb;15(2):320-6. doi: 10.1128/CVI.00381-07. Epub 2007 Dec 12.

DOI:10.1128/CVI.00381-07
PMID:18077612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2238046/
Abstract

Mycobacterium avium subsp. paratuberculosis is a zoonotic pathogen whose association with Crohn's disease in humans is under scrutiny. The objective of this work was to investigate its association with other chronic diseases such as type 1 diabetes mellitus (T1DM), where the involvement of a persistent pathogen such as M. avium subsp. paratuberculosis could be the trigger. For this purpose, 59 diabetic patients and 59 healthy controls were investigated for the presence of antibodies against two recombinant proteins of M. avium subsp. paratuberculosis and the whole-cell lysate. Extremely significant humoral immune responses to recombinant heparin binding hemagglutinin and glycosyl transferase proteins and the whole-cell lysates of M. avium subsp. paratuberculosis bacilli were observed in T1DM patients and compared to those of healthy controls. Finding evidence of M. avium subsp. paratuberculosis involvement in T1DM is perhaps a novel finding that might serve as a foundation stone in establishing an infectious etiology for T1DM.

摘要

副结核分枝杆菌是一种人畜共患病原体，其与人类克罗恩病的关联正在受到审查。这项工作的目的是研究其与其他慢性疾病的关联，如1型糖尿病（T1DM），在这类疾病中，像副结核分枝杆菌这样的持续性病原体的参与可能是触发因素。为此，对59名糖尿病患者和59名健康对照者进行了调查，以检测他们针对副结核分枝杆菌的两种重组蛋白和全细胞裂解物的抗体。在1型糖尿病患者中观察到了对重组肝素结合血凝素、糖基转移酶蛋白以及副结核分枝杆菌杆菌全细胞裂解物的极其显著的体液免疫反应，并与健康对照者的反应进行了比较。发现副结核分枝杆菌参与1型糖尿病的证据可能是一项新发现，这或许能作为确立1型糖尿病感染病因的基石。