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1型糖尿病患者对副结核分枝杆菌的体液免疫反应支持感染触发假说。

Humoral immune responses of type 1 diabetes patients to Mycobacterium avium subsp. paratuberculosis lend support to the infectious trigger hypothesis.

作者信息

Sechi Leonardo A, Rosu Valentina, Pacifico Adolfo, Fadda Giovanni, Ahmed Niyaz, Zanetti Stefania

机构信息

Dipartimento di Scienze Biomediche, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.

出版信息

Clin Vaccine Immunol. 2008 Feb;15(2):320-6. doi: 10.1128/CVI.00381-07. Epub 2007 Dec 12.

Abstract

Mycobacterium avium subsp. paratuberculosis is a zoonotic pathogen whose association with Crohn's disease in humans is under scrutiny. The objective of this work was to investigate its association with other chronic diseases such as type 1 diabetes mellitus (T1DM), where the involvement of a persistent pathogen such as M. avium subsp. paratuberculosis could be the trigger. For this purpose, 59 diabetic patients and 59 healthy controls were investigated for the presence of antibodies against two recombinant proteins of M. avium subsp. paratuberculosis and the whole-cell lysate. Extremely significant humoral immune responses to recombinant heparin binding hemagglutinin and glycosyl transferase proteins and the whole-cell lysates of M. avium subsp. paratuberculosis bacilli were observed in T1DM patients and compared to those of healthy controls. Finding evidence of M. avium subsp. paratuberculosis involvement in T1DM is perhaps a novel finding that might serve as a foundation stone in establishing an infectious etiology for T1DM.

摘要

副结核分枝杆菌是一种人畜共患病原体,其与人类克罗恩病的关联正在受到审查。这项工作的目的是研究其与其他慢性疾病的关联,如1型糖尿病(T1DM),在这类疾病中,像副结核分枝杆菌这样的持续性病原体的参与可能是触发因素。为此,对59名糖尿病患者和59名健康对照者进行了调查,以检测他们针对副结核分枝杆菌的两种重组蛋白和全细胞裂解物的抗体。在1型糖尿病患者中观察到了对重组肝素结合血凝素、糖基转移酶蛋白以及副结核分枝杆菌杆菌全细胞裂解物的极其显著的体液免疫反应,并与健康对照者的反应进行了比较。发现副结核分枝杆菌参与1型糖尿病的证据可能是一项新发现,这或许能作为确立1型糖尿病感染病因的基石。

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