西尼罗河病毒感染患者脉络膜视网膜炎相关因素的前瞻性评估。

A prospective evaluation of factors associated with chorioretinitis in patients with West Nile virus infection.

作者信息

Khairallah Moncef, Yahia Salim Ben, Letaief Mondher, Attia Sonia, Kahloun Rim, Jelliti Bechir, Zaouali Sonia, Messaoud Riadh

机构信息

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.

出版信息

Ocul Immunol Inflamm. 2007 Nov-Dec;15(6):435-9. doi: 10.1080/09273940701798488.

DOI:10.1080/09273940701798488

PMID:18085487

Abstract

PURPOSE

To identify factors associated with the development and severity of chorioretinitis (CR) in patients with West Nile virus (WNV) infection.

METHODS

Prospective study of 38 patients with WNV infection.

RESULTS

Simple analysis showed that diabetes (p = 0.027) and age older than 45 years (p = 0.03) were significantly associated with CR. When controlling for age, only association between diabetes and CR remains statistically significant. Diabetic patients' eyes were more likely to have macular involvement (p < 0.0001), 20 or more chorioretinal lesions (p < 0.001), and lesion size 500 microm or more (p < 0.01).

CONCLUSIONS

Diabetes was a risk factor for the development and severity of WNV-associated CR.

摘要

目的

确定与西尼罗河病毒（WNV）感染患者脉络膜视网膜炎（CR）的发生及严重程度相关的因素。

方法

对38例WNV感染患者进行前瞻性研究。

结果

单因素分析显示，糖尿病（p = 0.027）和年龄大于45岁（p = 0.03）与CR显著相关。在控制年龄后，仅糖尿病与CR之间的关联仍具有统计学意义。糖尿病患者的眼睛更易出现黄斑受累（p < 0.0001）、20个或更多脉络膜视网膜病变（p < 0.001）以及病变大小达500微米或更大（p < 0.01）。