Rousseau Antoine, Haigh Oscar, Ksiaa Imen, Khairallah Moncef, Labetoulle Marc
Department of Ophthalmology, Bicêtre Hospital, Public Assistance, Hospitals of Paris, Reference Network for Rare Diseases in Ophthalmology (OPHTARA), 94270 Le Kremlin-Bicêtre, France.
Center for Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB), Infectious Diseases Models for Innovative Therapies (IDMIT), French Alternative Energies and Atomic Commission (CEA), 92260 Fontenay-aux-Roses, France.
Vaccines (Basel). 2020 Nov 2;8(4):641. doi: 10.3390/vaccines8040641.
Ocular manifestations are a feature of West Nile virus infection. They mostly occur in association with severe neuroinvasive disease. Linear chorioretinitis is suggestive of the diagnosis and may raise diagnostic suspicion when associated with evocative systemic signs, and in an epidemic context. Various other less specific inflammatory ocular manifestations have been reported, including anterior uveitis, occlusive retinal vasculitis, optic neuritis, and diplopia. The pathophysiology of ocular disease remains unclear, but it reflects the neuroinvasiveness of the disease. Although ocular involvement most often resolves without visual sequelae, some patients may have permanent loss of vision, adding to the need for the development of a specific treatment and/or vaccines.
眼部表现是西尼罗河病毒感染的一个特征。它们大多与严重的神经侵袭性疾病相关。线状脉络膜视网膜炎提示诊断，当与引人联想的全身症状相关且处于流行背景下时，可能会提高诊断怀疑度。还报告了各种其他不太特异的炎症性眼部表现，包括前葡萄膜炎、闭塞性视网膜血管炎、视神经炎和复视。眼部疾病的病理生理学仍不清楚，但它反映了该疾病的神经侵袭性。尽管眼部受累大多可在无视力后遗症的情况下缓解，但一些患者可能会永久性视力丧失，这增加了开发特异性治疗方法和/或疫苗的必要性。
