一种用于禽流感病毒和新城疫病毒的鸡胚内联合疫苗。
A combination in-ovo vaccine for avian influenza virus and Newcastle disease virus.
作者信息
Steel John, Burmakina Svetlana V, Thomas Colleen, Spackman Erica, García-Sastre Adolfo, Swayne David E, Palese Peter
机构信息
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
出版信息
Vaccine. 2008 Jan 24;26(4):522-31. doi: 10.1016/j.vaccine.2007.11.032. Epub 2007 Dec 3.
Abstract
The protection of poultry from H5N1 highly pathogenic avian influenza A (HPAI) and Newcastle disease virus (NDV) can be achieved through vaccination, as part of a broader disease control strategy. We have previously generated a recombinant influenza virus expressing, (i) an H5 hemagglutinin protein, modified by the removal of the polybasic cleavage peptide and (ii) the ectodomain of the NDV hemagglutinin-neuraminidase (HN) protein in the place of the ectodomain of influenza neuraminidase (Park MS, et al. Proc Natl Acad Sci USA 2006;103(21):8203-8). Here we show this virus is attenuated in primary normal human bronchial epithelial (NHBE) cell culture, and demonstrate protection of C57BL/6 mice from lethal challenge with an H5 HA-containing influenza virus through immunisation with the recombinant virus. In addition, in-ovo vaccination of 18-day-old embryonated chicken eggs provided 90% and 80% protection against highly stringent lethal challenge by NDV and H5N1 virus, respectively. We propose that this virus has potential as a safe in-ovo live, attenuated, bivalent avian influenza and Newcastle disease virus vaccine.
摘要
作为更广泛疾病控制策略的一部分，通过疫苗接种可实现对家禽的H5N1高致病性甲型禽流感（HPAI）和新城疫病毒（NDV）的保护。我们之前已构建出一种重组流感病毒，其表达：（i）通过去除多碱性切割肽进行修饰的H5血凝素蛋白，以及（ii）用新城疫病毒血凝素 - 神经氨酸酶（HN）蛋白的胞外域替代流感神经氨酸酶胞外域（Park MS等人，《美国国家科学院院刊》2006年；103(21):8203 - 8）。在此我们表明，这种病毒在原代正常人支气管上皮（NHBE）细胞培养中减毒，并通过用重组病毒免疫证明其能保护C57BL / 6小鼠免受含H5 HA的流感病毒的致死性攻击。此外，对18日龄鸡胚进行卵内接种分别为其提供了90%和80%的保护，使其免受新城疫病毒和H5N1病毒高度严格的致死性攻击。我们提出，这种病毒有潜力作为一种安全的卵内活减毒二价禽流感和新城疫病毒疫苗。
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