Hosseinpanah Farhad, Rambod Mehdi, Hossein-nejad Arash, Larijani Bagher, Azizi Fereidoun
Obesity Research Center, Research Institute for Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, PO Box 193-4763, Tehran, Iran
J Bone Miner Metab. 2008;26(1):86-92. doi: 10.1007/s00774-007-0791-7. Epub 2008 Jan 10.
The role of vitamin-D in determining bone mineral density (BMD), especially in less severe vitamin D deficiency, is still unclear. To investigate the possible association between 25-hydroxyvitamin D [25(OH)D] and BMD, 245 healthy free-living postmenopausal women, aged between 40 and 80, were randomly selected from participants of a population-based study. BMD was measured at the lumbar spine and hip by dual X-ray absorptiometry (Lunar DPXMD 7164). Serum 25(OH)D, parathyroid hormone (PTH), calcium, phosphorus, total and bone alkaline phosphatases, and urine deoxypyridinoline were measured. PTH was logarithmically transformed (LnPTH). Linear regression models were developed to determine the association between serum 25(OH)D and BMD at different sites. Means of age and duration of menopause were 57.7 +/- 7 and 9.4 +/- 6.8 years, respectively. Mean 25(OH)D was 73.0 +/- 62.3 nmol/l; 5.3% (n = 13) had 25(OH)D < 25 nmol/l and 37.6% (n = 92) had 25(OH)D between 25 and 50 nmol/l. Eleven percent of the women (n = 27) were osteoporotic in femoral neck and 25.3% of them (n = 62) were osteoporotic in lumbar spine sites. 25(OH)D correlated inversely with LnPTH (r = -0.25, P < 0.01). In the multivariate analyses, no association was found between 25(OH)D and BMD at any of the skeletal sites after adjusting for age, duration of menopause, body mass index, calcium, and LnPTH. However, BMD was associated inversely with LnPTH only in femoral neck but not in the other sites. This study did not show any association between 25(OH)D and BMD in free-living Iranian postmenopausal women.
维生素D在决定骨矿物质密度（BMD）方面的作用，尤其是在不太严重的维生素D缺乏情况下，仍不明确。为了研究25-羟基维生素D [25(OH)D] 与BMD之间可能存在的关联，从一项基于人群的研究参与者中随机选取了245名年龄在40至80岁之间、健康且生活自理的绝经后女性。通过双能X线吸收法（Lunar DPXMD 7164）测量腰椎和髋部的骨密度。检测血清25(OH)D、甲状旁腺激素（PTH）、钙、磷、总碱性磷酸酶和骨碱性磷酸酶以及尿脱氧吡啶啉。对PTH进行对数转换（LnPTH）。建立线性回归模型以确定血清25(OH)D与不同部位骨密度之间的关联。年龄均值和绝经持续时间分别为57.7±7岁和9.4±6.8年。25(OH)D均值为73.0±62.3 nmol/l；5.3%（n = 13）的25(OH)D < 25 nmol/l，37.6%（n = 92）的25(OH)D在25至50 nmol/l之间。11%的女性（n = 27）股骨颈骨质疏松，25.3%（n = 62）的女性腰椎部位骨质疏松。25(OH)D与LnPTH呈负相关（r = -0.25，P < 0.01）。在多变量分析中，在调整年龄、绝经持续时间、体重指数、钙和LnPTH后，未发现25(OH)D与任何骨骼部位的骨密度之间存在关联。然而，仅在股骨颈部位骨密度与LnPTH呈负相关，其他部位则不然。本研究未显示生活自理的伊朗绝经后女性中25(OH)D与骨密度之间存在任何关联。
