Karasulu H Yesim
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ege, 35100 Bornova, Izmir, Turkey.
Expert Opin Drug Deliv. 2008 Jan;5(1):119-35. doi: 10.1517/17425247.5.1.119.
A microemulsion, made from water, oil, surfactants and cosurfactant is a thermodynamically stable system. The presence of the cosurfactant is often required in order to lower the interfacial tension of this interface, because a low interfacial tension is essential for the formation of microemulsions. The transparency of microemulsions arises from their small droplet diameter. The droplet diameter in stable microemulsions is usually within the range of 10 - 140 nm. Microemulsions are graphically represented as stability areas in triangular phase diagrams where each triangular corner designates a certain component. Microemulsions are actually quaternary (pseudoternary) systems. In pharmaceutical fields, the interest in microemulsions is increasing and, thus, they are applied to various administration routes.
由水、油、表面活性剂和助表面活性剂制成的微乳液是一种热力学稳定体系。通常需要助表面活性剂的存在来降低该界面的界面张力，因为低界面张力对于微乳液的形成至关重要。微乳液的透明度源于其小液滴直径。稳定微乳液中的液滴直径通常在10 - 140纳米范围内。微乳液在三角相图中以稳定区域的形式图形化表示，其中每个三角形角代表某一组分。微乳液实际上是四元（假三元）体系。在制药领域，对微乳液的兴趣日益增加，因此它们被应用于各种给药途径。
