Silverman S, Gorsky M, Lozada-Nur F
Oral Surg Oral Med Oral Pathol. 1985 Jul;60(1):30-4. doi: 10.1016/0030-4220(85)90210-5.
Five hundred seventy patients with oral lichen planus were followed for periods ranging from 6 months to more than 10 years (mean, 5.6 years). The mean age was 52 years, and 67% of the patients were women. Erosive lichen planus was the most frequent clinical form, and the buccal mucosa was the most common site. Of the 75% patients treated with corticosteroids, 29% experienced complete remission and 63% had partial remission while maintained on medication. Fewer than 3% experienced spontaneous remission. Malignant transformation occurred in 7 patients (1.2%) in a mean time of 3.4 years after the onset of lichen planus. The onset of lichen planus could not be associated with any evident factors, such as family history, Candida albicans, glucose intolerance, and smoking.
对570例口腔扁平苔藓患者进行了为期6个月至10多年（平均5.6年）的随访。平均年龄为52岁，67%的患者为女性。糜烂性扁平苔藓是最常见的临床类型，颊黏膜是最常见的发病部位。在接受皮质类固醇治疗的患者中，29%完全缓解，63%在持续用药期间部分缓解。不到3%的患者自发缓解。7例患者（1.2%）发生恶变，恶变平均发生在扁平苔藓发病后3.4年。扁平苔藓的发病与任何明显因素无关，如家族史、白色念珠菌、葡萄糖不耐受和吸烟。
