佐剂油可诱发DA大鼠患关节炎。I. 疾病特征及免疫参与的证据。
Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement.
作者信息
Kleinau S, Erlandsson H, Holmdahl R, Klareskog L
机构信息
Department of Medical and Physiological Chemistry, Uppsala University, Sweden.
出版信息
J Autoimmun. 1991 Dec;4(6):871-80. doi: 10.1016/0896-8411(91)90050-m.
Abstract
An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel A, as well as Pristane oil were arthritogenic, whereas vegetable oil were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.
摘要
皮内注射不含其他添加剂的弗氏不完全佐剂油（FIA）可使黑褐大鼠（DA大鼠）诱发侵蚀性多关节炎，但对刘易斯大鼠无效。组织学检查显示有关节炎症，最初为多形核细胞和滑膜增生，随后出现多核巨细胞。FIA的两种成分，矿物油和阿拉塞A以及角鲨烯油都具有致关节炎作用，而植物油则没有。恢复后再次注射佐剂油未能诱发关节炎，因此特异性免疫在大鼠这种新形式的关节炎中可能发挥作用。
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