拉丁裔医生的临床试验态度与实践
Clinical trials attitudes and practices of Latino physicians.
作者信息
Ramirez Amelie G, Wildes Kimberly, Talavera Greg, Nápoles-Springer Anna, Gallion Kipling, Pérez-Stable Eliseo J
机构信息
Institute for Health Promotion Research, Department of Epidemiology and Biostatistics, School of Medicine, University of Texas Health Science Center at San Antonio, TX 78230, USA.
出版信息
Contemp Clin Trials. 2008 Jul;29(4):482-92. doi: 10.1016/j.cct.2007.11.001. Epub 2007 Nov 21.
BACKGROUND
Ethnic differences in physicians' attitudes and behaviors related to clinical trials might partially account for disparities in clinical trial participation among Latino patients. Literature regarding Latino physicians' clinical trials attitudes and practices, in comparison to White physicians, was lacking.
METHODS
Cross-sectional data from randomly selected physicians (N=695), stratified by ethnicity, were analyzed to test associations of ethnicity with physicians' participation in and attitudes toward referral of patients to clinical trials.
RESULTS
Chi-square analyses showed significant (p<0.05) associations of physician race/ethnicity and clinical trials involvement, type of trial for which the physician is likely to recommend a patient, belief in scientific value, and factors that would influence recommendation for a patient to participate. Multivariate analyses resulted in several significant (p<0.05) predictors of clinical trials outcomes, including physician race/ethnicity.
CONCLUSIONS
Latino physicians were significantly less involved in clinical trials than White physicians and found less scientific value in them, highlighting areas for future education and intervention.
背景
医生在与临床试验相关的态度和行为上的种族差异可能部分解释了拉丁裔患者在临床试验参与方面的差异。与白人医生相比，缺乏关于拉丁裔医生对临床试验的态度和做法的文献。
方法
对按种族分层的随机选择的医生（N = 695）的横断面数据进行分析，以测试种族与医生参与临床试验以及将患者转诊至临床试验的态度之间的关联。
结果
卡方分析显示，医生的种族/民族与临床试验参与、医生可能推荐患者参加的试验类型、对科学价值的信念以及会影响推荐患者参与的因素之间存在显著（p<0.05）关联。多变量分析得出了几个对临床试验结果有显著（p<0.05）影响的预测因素，包括医生的种族/民族。
结论
拉丁裔医生参与临床试验的程度明显低于白人医生，并且认为临床试验的科学价值较低，这突出了未来教育和干预的领域。
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