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减肥手术后的生存率及合并症变化

Survival and changes in comorbidities after bariatric surgery.

作者信息

Perry Cynthia D, Hutter Matthew M, Smith Daniel B, Newhouse Joseph P, McNeil Barbara J

机构信息

The Urban Institute, 2100 M Street NW, Washington, DC 20037, USA.

出版信息

Ann Surg. 2008 Jan;247(1):21-7. doi: 10.1097/SLA.0b013e318142cb4b.

Abstract

OBJECTIVE

To evaluate survival rates and changes in weight-related comorbid conditions after bariatric surgery in a high-risk patient population as compared with a similar cohort of morbidly obese patients who did not undergo surgery.

SUMMARY BACKGROUND DATA

Morbid obesity is increasingly becoming a major public health issue. Existing studies are limited in their ability to assess the risks and benefits of bariatric surgery because few studies compare surgical patients to a similar, morbidly obese, nonsurgical cohort, especially in high-risk populations like the elderly and disabled.

METHODS

A retrospective cohort analysis using Medicare fee-for-service patients from 2001 to 2004. Survival rates and diagnosed presence of 5 conditions commonly comorbid with morbid obesity were examined for morbidly obese patients who did and did not undergo bariatric surgery, with up to 2 years follow-up.

RESULTS

Morbidly obese Medicare patients who underwent bariatric surgery had increased survival rates over the 2 years of this study when compared with a similar morbidly obese nonsurgical group (P < 0.001). For patients under the age of 65, this survival advantage started at 6 months postoperatively and for patients over age 65, at 11 months. The surgical group also experienced significant improvements in the diagnosed prevalence of 5 weight-related comorbid conditions (diabetes, sleep apnea, hypertension, hyperlipidemia, and coronary artery disease) relative to the nonsurgical cohort after 1 year postsurgery (P < 0.001).

CONCLUSIONS

Bariatric surgery appears to increase survival even in the high-risk, Medicare population, both for individuals aged 65 and older and those disabled and under 65. In addition, the diagnosed prevalence of weight-related comorbid conditions declined after bariatric surgery relative to a control cohort of morbidly obese patients who did not undergo surgery.

摘要

目的

评估高危患者群体接受减肥手术后的生存率以及与体重相关的合并症变化,并与未接受手术的类似病态肥胖患者队列进行比较。

总结背景数据

病态肥胖日益成为一个主要的公共卫生问题。现有研究在评估减肥手术的风险和益处方面能力有限,因为很少有研究将手术患者与类似的病态肥胖非手术队列进行比较,尤其是在老年人和残疾人等高风险人群中。

方法

采用回顾性队列分析,研究对象为2001年至2004年使用医疗保险按服务收费的患者。对接受和未接受减肥手术的病态肥胖患者的生存率以及5种通常与病态肥胖合并存在的疾病的诊断情况进行了检查,随访时间长达2年。

结果

与类似的病态肥胖非手术组相比,接受减肥手术的病态肥胖医疗保险患者在本研究的2年期间生存率有所提高(P < 0.001)。对于65岁以下的患者,这种生存优势在术后6个月开始显现,对于65岁以上的患者,则在11个月时开始显现。与非手术队列相比,手术组在术后1年时,5种与体重相关的合并症(糖尿病、睡眠呼吸暂停、高血压、高脂血症和冠状动脉疾病)的诊断患病率也有显著改善(P < 0.001)。

结论

减肥手术似乎能提高生存率,即使在医疗保险覆盖的高危人群中也是如此,无论是65岁及以上的个体,还是65岁以下的残疾个体。此外,与未接受手术的病态肥胖对照队列相比,减肥手术后与体重相关的合并症的诊断患病率有所下降。

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