天然野生小鼠白血病病毒的双嗜性宿主范围。
Amphotropic host range of naturally occuring wild mouse leukemia viruses.
作者信息
Rasheed S, Gardner M B, Chan E
出版信息
J Virol. 1976 Jul;19(1):13-8. doi: 10.1128/JVI.19.1.13-18.1976.
Abstract
Seven murine leukemia virus field isolates (uncloned) from wild mice (Musmusculus) of four widely separated areas in southern California show an unusually wide in vitro host range. They replicate well in human, feline, canine, guinea pig, rabbit, rat, and mouse cells, whereas bovine, hamster, and avian cells are resistant. Since this host range includes that of both mouse tropic (ecotropic) and xenotropic murine leukemia viruses, they are designated as "amphotropic". No purely xenotropic virus component is detectable in these field isolates. They may represent the "wild" or ancestral viruses from which the ecotropic and xenotrophic murine leukemia virus strains of laboratory mice have been derived.
摘要
从南加州四个相距甚远地区的野生小家鼠中分离出的七种鼠白血病病毒（未克隆）显示出异常广泛的体外宿主范围。它们能在人、猫、犬、豚鼠、兔、大鼠和小鼠细胞中良好复制，而牛、仓鼠和禽类细胞具有抗性。由于这种宿主范围包括嗜亲性（亲嗜性）和异嗜性鼠白血病病毒的宿主范围，它们被指定为“双嗜性”。在这些野外分离株中未检测到纯异嗜性病毒成分。它们可能代表了实验室小鼠的亲嗜性和异嗜性鼠白血病病毒株所衍生的“野生”或原始病毒。
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