白血病AKR小鼠肿瘤组织中AKR特异性序列的增加。
Increase of AKR-specific sequences in tumor tissues of leukemic AKR mice.
作者信息
Berns A, Jaenisch R
出版信息
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2448-52. doi: 10.1073/pnas.73.7.2448.
Abstract
AKR mice produce, from shortly after birth, high titers of their endogenous Gross type murine leukemia virus, and develop a thymus-derived leukemia at 7-9 months of age. We show that this oncogenesis is accompanied by an increase in the number of AKR-specific DNA sequences in the tumor tissues, whereas the "non-target" organs are not affected. Sequence increase was determined by kinetic analysis of DNA reassociation using an AKR-murine leukemia virus (MuLV)-specific cDNA and also by hybridization with excess AKR cDNA. The AKR cDNA was selected to recognize AKR sequences without significant crossreaction with DNA sequences of other endogenous viruses. The results show that during the development of the leukemia, the number of AKR-MuLV-specific genes increases in tumor tissues by a factor of 1 1/2 to 2.
摘要
AKR小鼠从出生后不久就会产生高滴度的内源性格罗斯型鼠白血病病毒，并在7至9个月大时发生胸腺源性白血病。我们发现，这种肿瘤发生伴随着肿瘤组织中AKR特异性DNA序列数量的增加，而“非靶”器官则不受影响。通过使用AKR-鼠白血病病毒（MuLV）特异性cDNA对DNA复性进行动力学分析，以及与过量的AKR cDNA杂交，确定了序列增加。选择AKR cDNA以识别与其他内源性病毒的DNA序列无明显交叉反应的AKR序列。结果表明，在白血病发展过程中，肿瘤组织中AKR-MuLV特异性基因的数量增加了1.5至2倍。
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Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal.用白血病病毒感染植入前小鼠胚胎和新生小鼠：病毒DNA和RNA的组织分布以及成年动物的白血病发生情况。
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Trisomy of chromosome 15 in spontaneous leukemia of AKR mice.AKR小鼠自发性白血病中15号染色体三体性
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