Lee Jeongrai, Kwon Suk-Hyung, Kim Hyun-Mi, Fahey Stefan N, Knighton Derek R, Sansom Andrew
RexGene Biotech Co., Ltd., Korea.
Biosci Biotechnol Biochem. 2008 Jan;72(1):1-6. doi: 10.1271/bbb.60695. Epub 2008 Jan 7.
Colostrum is a complex mixture of bioactives that promotes neonate growth. Studies show that it contains components capable of promoting bone formation and inhibiting bone resorption. Although many colostrum-based nutritional supplements have been developed as growth promotants, few studies have investigated their functional effects. A bovine colostrum 1-30 kDa fraction, Growth Protein-Colostrum (GP-C), was administered to juvenile rats as a dietary supplement to determine effects on growth and development. GP-C enhanced the growth and mineralization of the femur as evidenced by increased serum osteocalcin and bone mineral density. Increased levels of serum growth hormone and insulin-like growth factor-1 suggest that the mechanism of enhanced growth is partially controlled by endocrine factors. GP-C was also found to increase osteoblast proliferation in vitro, a finding that indicates a possible mechanism of action of GP-C, but further studies are required. Based on our findings, we hypothesize that a colostrum-based dietary supplement enhances bone growth and development in humans.
初乳是一种促进新生儿生长的生物活性物质的复杂混合物。研究表明，它含有能够促进骨形成和抑制骨吸收的成分。尽管已经开发出许多基于初乳的营养补充剂作为生长促进剂，但很少有研究调查它们的功能效果。将一种牛初乳1-30 kDa组分，即生长蛋白-初乳（GP-C），作为膳食补充剂给予幼鼠，以确定其对生长和发育的影响。GP-C增强了股骨的生长和矿化，血清骨钙素和骨矿物质密度的增加证明了这一点。血清生长激素和胰岛素样生长因子-1水平的升高表明，生长增强的机制部分受内分泌因素控制。还发现GP-C能增加体外成骨细胞的增殖，这一发现表明了GP-C可能的作用机制，但还需要进一步研究。基于我们的研究结果，我们推测基于初乳的膳食补充剂可增强人类的骨骼生长和发育。
