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比较吻合器痔上黏膜环切术与传统痔切除术的随机对照试验的系统评价和荟萃分析

Systematic review and meta-analysis of randomized controlled trials comparing stapled haemorrhoidopexy with conventional haemorrhoidectomy.

作者信息

Shao W-J, Li G-C H, Zhang Z H-K, Yang B-L, Sun G-D, Chen Y-Q

机构信息

Department of Coloproctology, Nanjing TCM University Hospital, Nanjing, China.

出版信息

Br J Surg. 2008 Feb;95(2):147-60. doi: 10.1002/bjs.6078.

Abstract

BACKGROUND

This paper compares stapled haemorrhoidopexy with conventional haemorrhoidectomy for the treatment of haemorrhoids.

METHODS

An electronic literature search was undertaken to identify primary studies and systematic reviews. Results on efficacy and safety were analysed. A meta-analysis was conducted to examine long-term outcomes.

RESULTS

Twenty-nine randomized clinical trials recruiting 2056 patients were identified. Meta-analysis showed that stapled haemorrhoidopexy was less painful than conventional haemorrhoidectomy. Stapled haemorrhoidopexy required a shorter inpatient stay (weighted mean difference (WMD) -0.95 (95 per cent confidence interval (c.i.) -1.32 to -0.59) days; P < 0.001) and operating time (WMD -11.42 (95 per cent c.i. -18.26 to -4.59) min; P = 0.001). It was also associated with a faster return to normal activities (WMD -11.75 (95 per cent c.i. -21.42 to -2.08) days; P = 0.017). No significant difference was noted between the two techniques in terms of the total incidence of complications. Stapled haemorrhoidopexy was associated with a higher rate of recurrent disease (relative risk 2.29 (95 per cent c.i. 1.57 to 3.33); P < 0.001).

CONCLUSION

Stapled haemorrhoidopexy offers some short-term benefits over conventional operation but the total complication rates are similar for both techniques. Stapled haemorrhoidopexy is associated with a higher rate of recurrent disease.

摘要

背景

本文比较吻合器痔上黏膜环切术与传统痔切除术治疗痔疮的效果。

方法

进行电子文献检索以确定原始研究和系统评价。分析疗效和安全性结果。进行荟萃分析以检查长期结局。

结果

共纳入29项随机临床试验,涉及2056例患者。荟萃分析表明,吻合器痔上黏膜环切术比传统痔切除术疼痛轻。吻合器痔上黏膜环切术住院时间较短(加权平均差(WMD)-0.95(95%置信区间(c.i.)-1.32至-0.59)天;P<0.001),手术时间较短(WMD -11.42(95% c.i. -18.26至-4.59)分钟;P = 0.001)。恢复正常活动也更快(WMD -11.75(95% c.i. -21.42至-2.08)天;P = 0.017)。两种技术在并发症总发生率方面无显著差异。吻合器痔上黏膜环切术复发率较高(相对风险2.29(95% c.i. 1.57至3.33);P<0.001)。

结论

吻合器痔上黏膜环切术比传统手术有一些短期优势,但两种技术的总并发症发生率相似。吻合器痔上黏膜环切术复发率较高。

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