纳米颗粒在泌尿外科恶性肿瘤治疗性消融中的新兴应用。

Emerging use of nanoparticles for the therapeutic ablation of urologic malignancies.

作者信息

Stern Joshua M, Cadeddu Jeffrey A

机构信息

Center for Minimally Invasive Urologic Cancer Treatment, Department of Urology, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

Urol Oncol. 2008 Jan-Feb;26(1):93-6. doi: 10.1016/j.urolonc.2007.03.019.

DOI:10.1016/j.urolonc.2007.03.019

PMID:18190837

Abstract

Metal nanoshells are a new class of nanoparticle with highly tunable optical properties. Gold nanoshells (GNS) are particularly suitable for use in the surgical arena as their outer shell is composed of a commonly used reduced inert gold. When activated by near infrared light, GNS can raise surrounding temperatures to levels sufficient for cellular ablation. As such, investigators have established both in vitro and in vivo models to examine the role of GNS as a therapeutic modality for the thermal ablation of solid organ tumors.

摘要

金属纳米壳是一类新型纳米颗粒，具有高度可调节的光学特性。金纳米壳（GNS）特别适合用于外科领域，因为其外壳由常用的还原惰性金组成。当被近红外光激活时，金纳米壳可以将周围温度升高到足以进行细胞消融的水平。因此，研究人员已经建立了体外和体内模型，以研究金纳米壳作为实体器官肿瘤热消融治疗方式的作用。