金纳米颗粒作为癌症治疗的新型制剂。
Gold nanoparticles as novel agents for cancer therapy.
机构信息
Northern Ireland Cancer Centre, Queens University Belfast, Belfast, UK.
出版信息
Br J Radiol. 2012 Feb;85(1010):101-13. doi: 10.1259/bjr/59448833. Epub 2011 Oct 18.
Abstract
Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. This review introduces the field of nanotechnology with a focus on recent gold nanoparticle research which has led to early-phase clinical trials. In particular, the pre-clinical evidence for gold nanoparticles as sensitisers with ionising radiation in vitro and in vivo at kilovoltage and megavoltage energies is discussed.
摘要
金纳米颗粒作为癌症治疗的有前途的药物正在被研究作为药物载体、光热剂、对比剂和放射增敏剂。本综述介绍了纳米技术领域，重点介绍了最近的金纳米颗粒研究，这些研究已导致早期临床试验。特别是，讨论了金纳米颗粒作为千伏和兆伏能量下体外和体内电离辐射增敏剂的临床前证据。
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