猪扁桃体放线杆菌中的小多药耐药质粒
Small multidrug resistance plasmids in Actinobacillus porcitonsillarum.
作者信息
Matter Denise, Rossano Alexandra, Sieber Sandra, Perreten Vincent
机构信息
Institute of Veterinary Bacteriology, University of Berne, Länggass-Strasse 122, Postfach, CH-3001 Bern, Switzerland.
出版信息
Plasmid. 2008 Mar;59(2):144-52. doi: 10.1016/j.plasmid.2007.11.003. Epub 2008 Jan 10.
The complete nucleotide sequences of six Actinobacillus porcitonsillarum plasmids pKMA202 (13.425-kb), pKMA1467 (11.115-kb), pKMA5 (9.549-kb), pIMD50 (8.751-kb), pKMA505 (8.632-kb) and pKMA757 (4.556-kb) and three Actinobacillus pleuropneumoniae plasmids pPSAS1522 (4.244-kb), pARD3079 (3.884-kb) and pKMA2425 (3.156-kb) were determined. All the plasmids contain the sulfonamide resistance gene sul2. One A. pleuropneumoniae plasmid and five A. porcitonsillarum plasmids also have the streptomycin resistance gene strA. Among these latter five A. porcitonsillarum plasmids, four also harbor the beta-lactam resistance gene bla(ROB-1). This study is the first report of multidrug resistance plasmids in the non-pathogenic A. porcitonsillarum.
测定了6个猪扁桃体放线杆菌质粒pKMA202（13.425kb）、pKMA1467（11.115kb）、pKMA5（9.549kb）、pIMD50（8.751kb）、pKMA505（8.632kb）和pKMA757（4.556kb）以及3个胸膜肺炎放线杆菌质粒pPSAS1522（4.244kb）、pARD3079（3.884kb）和pKMA2425（3.156kb）的完整核苷酸序列。所有质粒均含有磺胺类抗性基因sul2。1个胸膜肺炎放线杆菌质粒和5个猪扁桃体放线杆菌质粒还具有链霉素抗性基因strA。在这5个猪扁桃体放线杆菌质粒中，有4个还携带β-内酰胺抗性基因bla(ROB-1)。本研究首次报道了非致病性猪扁桃体放线杆菌中的多重耐药质粒。
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