DeLeve L D, Kaplowitz N
University of Southern California, Division of Gastrointestinal and Liver Diseases, Los Angeles.
Pharmacol Ther. 1991 Dec;52(3):287-305. doi: 10.1016/0163-7258(91)90029-l.
Glutathione (GSH) fulfills several essential functions: Detoxification of free radicals and toxic oxygen radicals, thiol-disulfide exchange and storage and transfer of cysteine. GSH is present in all mammalian cells, but may be especially important for organs with intense exposure to exogenous toxins such as the liver, kidney, lung and intestine. Within the cell mitochondrial GSH is the main defense against physiological oxidant stress generated by cellular respiration and may be a critical target for toxic oxygen and electrophilic metabolites. Glutathione homeostasis is a highly complex process, which is predominantly regulated by the liver, lung and kidney.
谷胱甘肽（GSH）具有多种重要功能：清除自由基和有毒氧自由基、硫醇-二硫键交换以及半胱氨酸的储存和转运。GSH存在于所有哺乳动物细胞中，但对于那些大量接触外源性毒素的器官，如肝脏、肾脏、肺和肠道，可能尤为重要。在细胞内，线粒体GSH是抵御细胞呼吸产生的生理氧化应激的主要防线，并且可能是有毒氧和亲电代谢产物的关键作用靶点。谷胱甘肽稳态是一个高度复杂的过程，主要由肝脏、肺和肾脏调节。
