Li Chuan, Liu K K
School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Ave., Singapore, Singapore 639798.
J Mater Sci Mater Med. 2008 Apr;19(4):1529-35. doi: 10.1007/s10856-008-3382-9. Epub 2008 Jan 24.
Deformation behaviours of red blood cells (RBCs) have been studied by applying stretching forces via optical tweezers. Combined with finite-element analyses (FEA), the RBCs' mechanical properties are determined quantitatively based on a best fitting between the experimental deformed geometries and the simulated counterparts. Experimentally, a silica beads attached erythrocyte is optical-mechanically stretched to different lengths. On the theoretical front, a large deformation model with Mooney-Rivlin constitutive equations has been simulated by using FEA to predict the cell deformation geometries. The numerically simulated transverse and longitudinal strains which are in a good agreement with the experimental measurements facilitate the determination of elastic constants of the cells.
通过光镊施加拉伸力来研究红细胞（RBC）的变形行为。结合有限元分析（FEA），基于实验变形几何形状与模拟对应物之间的最佳拟合，定量确定红细胞的力学性能。在实验方面，将附着有二氧化硅珠的红细胞进行光机械拉伸至不同长度。在理论方面，使用有限元分析对具有穆尼-里夫林本构方程的大变形模型进行了模拟，以预测细胞变形几何形状。数值模拟的横向和纵向应变与实验测量结果高度吻合，有助于确定细胞的弹性常数。
