Kubo Ai, Levin T R, Block Gladys, Rumore Gregory J, Quesenberry Charles P, Buffler Patricia, Corley Douglas A
Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.
Am J Epidemiol. 2008 Apr 1;167(7):839-46. doi: 10.1093/aje/kwm381. Epub 2008 Jan 23.
The objective of this study was to examine the associations between dietary patterns and the risk of Barrett's esophagus, a precursor to esophageal adenocarcinoma. The authors conducted a case-control study within the Kaiser Permanente Northern California population between 2002 and 2005. Patients with a new diagnosis of Barrett's esophagus (n = 296 cases) were matched to persons with gastroesophageal reflux disease (n = 308) without Barrett's esophagus and to population controls (n = 309). Dietary information was obtained from a validated, 110-item food frequency questionnaire. A principal component analysis was used to identify major dietary patterns. Two major dietary patterns were "Western" (high in fast food and meat) and "health-conscious" (high in fruits, vegetables, and nonfried fish). When cases and population controls were compared, strong adherence to the health-conscious dietary pattern was inversely associated with Barrett's esophagus (odds ratio = 0.35, 95% confidence interval: 0.20, 0.64; fourth vs. first quartile comparison). In contrast, data suggested an adverse effect of the Western dietary pattern on the risk of Barrett's esophagus, although no dose-effect relation was found. Results suggest strong associations between a diet rich in fruits and vegetables and the risk of Barrett's esophagus.
本研究的目的是探讨饮食模式与巴雷特食管（食管腺癌的癌前病变）风险之间的关联。作者于2002年至2005年在北加利福尼亚州凯撒医疗集团人群中开展了一项病例对照研究。新诊断为巴雷特食管的患者（n = 296例）与无巴雷特食管的胃食管反流病患者（n = 308例）及人群对照（n = 309例）进行匹配。饮食信息通过一份经验证的包含110个条目的食物频率问卷获取。采用主成分分析来确定主要饮食模式。两种主要饮食模式为“西方型”（快餐和肉类摄入量高）和“注重健康型”（水果、蔬菜和非油炸鱼类摄入量高）。当比较病例组与人群对照组时，严格遵循注重健康的饮食模式与巴雷特食管呈负相关（比值比 = 0.35，95%置信区间：0.20，0.64；第四分位数与第一分位数比较）。相比之下，数据表明西方饮食模式对巴雷特食管风险有不良影响，尽管未发现剂量效应关系。结果提示富含水果和蔬菜的饮食与巴雷特食管风险之间存在密切关联。
