缩小实验在柠檬酸生物合成研究中的应用。
Application of scale-down experiments in the study of citric acid biosynthesis.
作者信息
Ettler P, Martínková L, Ujcová E, Seichert L
机构信息
Department of Biotechnology, Institute of Microbiology, Czechoslovak Academy of Sciences, Prague.
出版信息
Folia Microbiol (Praha). 1991;36(5):493-7. doi: 10.1007/BF02884071.
Problems associated with the development of submersed citric acid biosynthesis on sugar beet molasses for process improvement were solved by scale-down experiments: the determination of optimal temperature profile, optimal pH value, influence of OTR and inoculum quality. The optimal pH value at the start of the process was 6.4 with 3% of inoculum volume and temperature profile between 28-30 degrees C. In the case of OTR which is scale-dependent, we prefer to use DOC pilot plant data for the transfer of technology.
通过缩小规模实验解决了与在甜菜糖蜜上进行浸没式柠檬酸生物合成以改进工艺相关的问题
确定最佳温度曲线、最佳pH值、OTR的影响和接种物质量。该工艺开始时的最佳pH值为6.4，接种物体积为3%，温度曲线在28 - 30摄氏度之间。对于与规模相关的OTR，我们更倾向于使用中试工厂数据来进行技术转移。
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