Park Bonggoo, Nizet Victor, Liu George Y
Division of Pediatric Infectious Diseases and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
J Bacteriol. 2008 Apr;190(7):2275-8. doi: 10.1128/JB.00006-08. Epub 2008 Jan 25.
Nasal colonization by Staphylococcus aureus is a major predisposing factor for subsequent infection. Recent reports of increased S. aureus colonization among children receiving pneumococcal vaccine implicate Streptococcus pneumoniae as an important competitor for the same niche. Since S. pneumoniae uses H2O2 to kill competing bacteria, we hypothesized that oxidant defense could play a significant role in promoting S. aureus colonization of the nasal mucosa. Using targeted mutagenesis, we showed that S. aureus expression of catalase contributes significantly to the survival of this pathogen in the presence of S. pneumoniae both in vitro and in a murine model of nasal cocolonization.
金黄色葡萄球菌在鼻腔的定植是随后感染的主要诱发因素。近期有报告称，接种肺炎球菌疫苗的儿童中金黄色葡萄球菌定植增加，这表明肺炎链球菌是同一生态位的重要竞争者。由于肺炎链球菌利用过氧化氢杀死竞争性细菌，我们推测氧化防御可能在促进金黄色葡萄球菌在鼻黏膜定植中发挥重要作用。通过靶向诱变，我们发现，在体外和鼻共同定植的小鼠模型中，金黄色葡萄球菌过氧化氢酶的表达对该病原体在肺炎链球菌存在时的存活有显著贡献。
