A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences , Moscow , Russia.
Institute of Laser and Information Technologies, Russian Academy of Sciences , Moscow , Russia.
Front Bioeng Biotechnol. 2015 Jun 8;3:81. doi: 10.3389/fbioe.2015.00081. eCollection 2015.
Biocompatible calcium phosphate ceramic grafts are able of supporting new bone formation in appropriate environment. The major limitation of these materials usage for medical implants is the absence of accessible methods for their patient-specific fabrication. 3D printing methodology is an excellent approach to overcome the limitation supporting effective and fast fabrication of individual complex bone substitutes. Here, we proposed a relatively simple route for 3D printing of octacalcium phosphates (OCP) in complexly shaped structures by the combination of inkjet printing with post-treatment methodology. The printed OCP blocks were further implanted in the developed cranial bone defect followed by histological evaluation. The obtained result confirmed the potential of the developed OCP bone substitutes, which allowed 2.5-time reducing of defect's diameter at 6.5 months in a region where native bone repair is extremely inefficient.
生物相容性磷酸钙陶瓷移植物能够在适当的环境中支持新骨形成。这些材料用于医疗植入物的主要限制是缺乏针对患者个体的制造方法。3D 打印方法是克服这一限制的绝佳方法，可以有效地快速制造个体化的复杂骨替代物。在这里，我们提出了一种通过喷墨打印与后处理方法相结合来 3D 打印复杂形状结构的八钙磷酸盐（OCP）的相对简单的方法。进一步将打印的 OCP 块植入已开发的颅骨缺损中，然后进行组织学评估。获得的结果证实了所开发的 OCP 骨替代物的潜力，在 6.5 个月时，在原生骨修复效率极低的区域，该替代物将缺陷直径缩小了 2.5 倍。
