白细胞毛细血管迁移：一种依赖黏附的现象。
Leucocyte capillary migration: an adherence dependent phenomenon.
作者信息
Lomnitzer R, Rabson A R, Koornhof H J
出版信息
Clin Exp Immunol. 1976 Aug;25(2):303-10.
To determine the mode of action of leucocyte inhibitory factor (LIF) on polymorphonuclear leucocyte (PMN) migration out of capillary tubes, this phenomenon has been compared with PMN adhesion to cotton wool columns. Colchicine and vinblastine sulphate had no effect on either of these processes but cytochalasin B caused marked inhibition of PMN migration and increased PMN adhesion. The cytochalasin B effect could be reversed in the presence of drugs known to increase intracellular levels of cyclic AMP. For inhibition of PMN migration by LIF, Mg2+ but not Ca2+ was essential. LIF not only inhibited PMN migration but also increased PMN adhesion to cotton wool columns. LIF inhibitory activity on PMN migration was not affected by colchicine or vinblastine. Leucocyte migration and adhesion depend on similar mechanisms, and are both influenced by LIF which probably acts by affecting micro-filament function.
为了确定白细胞抑制因子（LIF）对多形核白细胞（PMN）从毛细管中迁移出来的作用方式，已将此现象与PMN对棉纤维柱的黏附进行了比较。秋水仙碱和硫酸长春碱对这两个过程均无影响，但细胞松弛素B可显著抑制PMN迁移并增加PMN黏附。在已知可增加细胞内环磷酸腺苷（cAMP）水平的药物存在的情况下，细胞松弛素B的作用可被逆转。对于LIF抑制PMN迁移而言，Mg2+而非Ca2+是必不可少的。LIF不仅抑制PMN迁移，还增加PMN对棉纤维柱的黏附。LIF对PMN迁移的抑制活性不受秋水仙碱或长春碱的影响。白细胞迁移和黏附依赖于相似的机制，并且两者均受LIF影响，LIF可能通过影响微丝功能发挥作用。
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