环磷酸腺苷对白细胞抑制因子（LIF）产生及白细胞迁移抑制的影响。
The effects of cyclic AMP on leucocyte inhibitory factor (LIF) production and on the inhibition of leucocyte migration.
作者信息
Lomnitzer R, Rabson A R, Koornhof H J
出版信息
Clin Exp Immunol. 1976 Apr;24(1):42-8.
The effect of drugs known to increase intracellular levels of cyllic AMP were studied in the leucocyte migration ihibition system. It was found that cyclic AMP, dibutyryl cyclic AMP, theophyline, and prostaglandins E1 and E2 inhibited the production of leucocyte inhibiting factor by HA pulsed lymphocytes Inhibition only occured when the drugs were present during or after the PHA pulse. In addition it was found that these drugs enhanced the migration of polymorphonuclear leucocytes (PMN), in this system. Electrophoretic mobility of PMN cells was not altered by these drug indicating that the effect is not due to changes in membrane charge. However, granulocyte adhesion was reduced in the presence of these drug suggesting that adhesion is of primary importance in the migration of polymorphonuclear leucocytes out of capillary tubes. The findings show that cyclic AMP is important in modulating both cell-mediated and inflammatory responses.
在白细胞迁移抑制系统中研究了已知可增加细胞内环磷酸腺苷（cAMP）水平的药物的作用。发现环磷酸腺苷、二丁酰环磷酸腺苷、茶碱以及前列腺素E1和E2可抑制由PHA脉冲淋巴细胞产生的白细胞抑制因子。只有当药物在PHA脉冲期间或之后存在时才会出现抑制作用。此外，还发现在该系统中这些药物可增强多形核白细胞（PMN）的迁移。这些药物并未改变PMN细胞的电泳迁移率，表明该作用并非由于膜电荷的变化。然而，在这些药物存在的情况下粒细胞黏附减少，提示黏附在多形核白细胞从毛细血管中迁移出来的过程中起主要作用。研究结果表明，环磷酸腺苷在调节细胞介导的反应和炎症反应中都很重要。
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