Carter Robert H, Myers Riley
Department of Medicine, University of Alabama at Birmingham, Birmingham VAMC, Birmingham, Alabama, United States.
Semin Immunol. 2008 Feb;20(1):43-8. doi: 10.1016/j.smim.2007.12.007. Epub 2008 Feb 19.
The germinal center is a critical locus in the production of protective immunity, but its function is poorly understood. Studies of mutant forms of CD19 revealed differences in signaling in different compartments inside the germinal center, and structural findings indicate a selective role in the interaction with follicular dendritic cells in the GC. Loss of these signals leads to surprising changes in germinal center B cells that challenge previous models of GC function.
生发中心是产生保护性免疫的关键位点,但其功能尚不清楚。对CD19突变形式的研究揭示了生发中心内不同区域信号传导的差异,并且结构研究表明其在生发中心与滤泡树突状细胞相互作用中具有选择性作用。这些信号的缺失导致生发中心B细胞出现惊人变化,这对先前的生发中心功能模型提出了挑战。