用于美国食品药品监督管理局（FDA）屈光手术、手术器械以及新型眼内药物和溶液临床试验的角膜内皮细胞镜检查综述。
Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions.
作者信息
McCarey Bernard E, Edelhauser Henry F, Lynn Michael J
机构信息
Department of Ophthalmology, Emory University, Atlanta, GA, USA.
出版信息
Cornea. 2008 Jan;27(1):1-16. doi: 10.1097/ICO.0b013e31815892da.
Abstract
Specular microscopy can provide a noninvasive morphologic analysis of the corneal endothelial cell layer from subjects enrolled in clinical trials. The analysis provides a measure of the endothelial cell physiologic reserve from aging, ocular surgical procedures, pharmaceutical exposure, and general health of the corneal endothelium. The purpose of this review is to discuss normal and stressed endothelial cell morphology, the techniques for determining the morphology parameters, and clinical trial applications.
摘要
镜面显微镜检查可为参与临床试验的受试者的角膜内皮细胞层提供无创形态学分析。该分析可衡量内皮细胞因衰老、眼科手术、药物暴露及角膜内皮的整体健康状况而产生的生理储备。本综述的目的是讨论正常及应激状态下的内皮细胞形态、确定形态学参数的技术以及在临床试验中的应用。
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