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Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions.用于美国食品药品监督管理局(FDA)屈光手术、手术器械以及新型眼内药物和溶液临床试验的角膜内皮细胞镜检查综述。
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2
Magnification changes in specular microscopy after corneal refractive surgery.角膜屈光手术后镜面反射显微镜检查中的放大率变化
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The resiliency of the corneal endothelium to refractive and intraocular surgery.角膜内皮对屈光手术和眼内手术的耐受性
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Comparison of endothelial cell count using confocal and contact specular microscopy.使用共聚焦显微镜和接触式镜面反射显微镜对内皮细胞计数的比较。
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本文引用的文献

1
The balance between corneal transparency and edema: the Proctor Lecture.角膜透明度与水肿之间的平衡:普罗克特讲座
Invest Ophthalmol Vis Sci. 2006 May;47(5):1754-67. doi: 10.1167/iovs.05-1139.
2
Specular microscopy ancillary study methods for donor endothelial cell density determination of Cornea Donor Study images.用于角膜供体研究图像中供体内皮细胞密度测定的镜面显微镜辅助研究方法。
Curr Eye Res. 2006 Apr;31(4):319-27. doi: 10.1080/02713680500536738.
3
An evaluation of image quality and accuracy of eye bank measurement of donor cornea endothelial cell density in the Specular Microscopy Ancillary Study.角膜内皮细胞密度测量辅助研究中眼库对供体角膜内皮细胞密度的图像质量和准确性评估。
Ophthalmology. 2005 Mar;112(3):431-40. doi: 10.1016/j.ophtha.2004.10.045.
4
Predicting endothelial cell loss and long-term corneal graft survival.预测内皮细胞丢失和角膜移植的长期存活情况。
Invest Ophthalmol Vis Sci. 2003 Aug;44(8):3326-31. doi: 10.1167/iovs.02-1255.
5
Increased endothelial cell density in the paracentral and peripheral regions of the human cornea.人角膜中央旁和周边区域内皮细胞密度增加。
Am J Ophthalmol. 2003 May;135(5):584-90. doi: 10.1016/s0002-9394(02)02237-7.
6
Behavior of corneal endothelial density over a lifetime.角膜内皮密度在一生中的变化情况。
J Cataract Refract Surg. 2001 Oct;27(10):1574-8. doi: 10.1016/s0886-3350(01)00925-7.
7
Two-year corneal endothelial cell assessment following INTACS implantation.INTACS植入术后两年角膜内皮细胞评估。
J Refract Surg. 2001 Sep-Oct;17(5):542-8. doi: 10.3928/1081-597X-20010901-07.
8
The resiliency of the corneal endothelium to refractive and intraocular surgery.角膜内皮对屈光手术和眼内手术的耐受性
Cornea. 2000 May;19(3):263-73. doi: 10.1097/00003226-200005000-00002.
9
Assessment of the reliability of human corneal endothelial cell-density estimates using a noncontact specular microscope.使用非接触式角膜内皮显微镜评估人角膜内皮细胞密度估计值的可靠性。
Cornea. 2000 Mar;19(2):148-58. doi: 10.1097/00003226-200003000-00006.
10
Comparison of recording systems and analysis methods in specular microscopy.镜面显微镜检查中记录系统与分析方法的比较
Cornea. 1999 Jul;18(4):416-23. doi: 10.1097/00003226-199907000-00005.

用于美国食品药品监督管理局(FDA)屈光手术、手术器械以及新型眼内药物和溶液临床试验的角膜内皮细胞镜检查综述。

Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions.

作者信息

McCarey Bernard E, Edelhauser Henry F, Lynn Michael J

机构信息

Department of Ophthalmology, Emory University, Atlanta, GA, USA.

出版信息

Cornea. 2008 Jan;27(1):1-16. doi: 10.1097/ICO.0b013e31815892da.

DOI:10.1097/ICO.0b013e31815892da
PMID:18245960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3062434/
Abstract

Specular microscopy can provide a noninvasive morphologic analysis of the corneal endothelial cell layer from subjects enrolled in clinical trials. The analysis provides a measure of the endothelial cell physiologic reserve from aging, ocular surgical procedures, pharmaceutical exposure, and general health of the corneal endothelium. The purpose of this review is to discuss normal and stressed endothelial cell morphology, the techniques for determining the morphology parameters, and clinical trial applications.

摘要

镜面显微镜检查可为参与临床试验的受试者的角膜内皮细胞层提供无创形态学分析。该分析可衡量内皮细胞因衰老、眼科手术、药物暴露及角膜内皮的整体健康状况而产生的生理储备。本综述的目的是讨论正常及应激状态下的内皮细胞形态、确定形态学参数的技术以及在临床试验中的应用。