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大肠杆菌染色体上一个新发现的DNA复制终止位点TerE。

A newly identified DNA replication terminus site, TerE, on the Escherichia coli chromosome.

作者信息

Hidaka M, Kobayashi T, Horiuchi T

机构信息

Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.

出版信息

J Bacteriol. 1991 Jan;173(1):391-3. doi: 10.1128/jb.173.1.391-393.1991.

DOI:10.1128/jb.173.1.391-393.1991
PMID:1824765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC207198/
Abstract

To search for heretofore unidentified DNA replication termination (Ter) sites on the Escherichia coli chromosome, we screened the entire Kohara lambda bacteriophage library using as probes the four known 22-bp Ter sequences. We found a Ter site, which we named TerE, located at 23.2 min on the linkage map. TerE inhibits only counterclockwise DNA replication. Macroscopically, five Ter sites are located in a periodic arrangement on the genome.

摘要

为了在大肠杆菌染色体上寻找此前未被鉴定的DNA复制终止（Ter）位点，我们使用四个已知的22碱基对的Ter序列作为探针，筛选了整个小原噬菌体文库。我们发现了一个Ter位点，位于连锁图上23.2分钟处，我们将其命名为TerE。TerE仅抑制逆时针方向的DNA复制。从宏观上看，五个Ter位点在基因组上呈周期性排列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cae/207198/93da3aea572c/jbacter00091-0414-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cae/207198/93da3aea572c/jbacter00091-0414-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cae/207198/93da3aea572c/jbacter00091-0414-a.jpg

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1
A newly identified DNA replication terminus site, TerE, on the Escherichia coli chromosome.大肠杆菌染色体上一个新发现的DNA复制终止位点TerE。
J Bacteriol. 1991 Jan;173(1):391-3. doi: 10.1128/jb.173.1.391-393.1991.
2
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3
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Replication termini in the rDNA of synchronized pea root cells (Pisum sativum).豌豆根细胞（Pisum sativum）同步化时 rDNA 中的复制末端。
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The DNA replication fork blocked at the Ter site may be an entrance for the RecBCD enzyme into duplex DNA.在Ter位点受阻的DNA复制叉可能是RecBCD酶进入双链DNA的入口。
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A unique DNA intermediate associated with termination of chromosome replication in Bacillus subtilis.一种与枯草芽孢杆菌染色体复制终止相关的独特DNA中间体。
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