玉米赤霉烯酮向玉米赤霉烯酮硫酸盐的微生物转化。
Microbial transformation of zearalenone to a zearalenone sulfate.
作者信息
el-Sharkaway S H, Selim M I, Afifi M S, Halaweish F T
机构信息
Department of Medicinal Chemistry, College of Pharmacy, University of Iowa, Iowa City 52240.
出版信息
Appl Environ Microbiol. 1991 Feb;57(2):549-52. doi: 10.1128/aem.57.2.549-552.1991.
Abstract
The conversion of zearalenone by various microorganisms was studied. A new polar metabolite was formed in addition to alpha- and beta-zearalenols. The structure of the new metabolite was determined as zearalenone-4-O-sulfate conjugate on the basis of enzymatic and acid hydrolysis, followed by mass spectrometry, nuclear magnetic resonance, and infrared spectroscopic analysis. The results obtained demonstrate that Rhizopus arrhizus catalyzes sulfation of zearalenone at the C-4 hydroxyl group.
摘要
研究了多种微生物对玉米赤霉烯酮的转化。除了α-和β-玉米赤霉烯醇外，还形成了一种新的极性代谢产物。基于酶解和酸水解，随后进行质谱、核磁共振和红外光谱分析，确定新代谢产物的结构为玉米赤霉烯酮-4-O-硫酸酯共轭物。所得结果表明，米根霉催化玉米赤霉烯酮在C-4羟基处的硫酸化反应。
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