附着在核孔上的纤维状结构阻止了SV40病毒颗粒从被感染的细胞核中逸出。
Fibrils attached to the nuclear pore prevent egress of SV40 particles from the infected nucleus.
作者信息
Maul G G
出版信息
J Cell Biol. 1976 Sep;70(3):714-9. doi: 10.1083/jcb.70.3.714.
Abstract
SV40 particles can apparently enter the nucleus intact. However, they do not leave the nucleus despite the high concentration present during the productive phase. We found structural evidence that SV40 virus is prevented from approaching the most likely site of exit, the nuclear pore complex. From these images, it is concluded that the fibrils attached to the nuclear pore complex prevent egress of SV40 particles from the infected nucleus.
摘要
SV40病毒颗粒显然能够完整地进入细胞核。然而，尽管在增殖阶段存在高浓度的病毒颗粒，它们却无法离开细胞核。我们发现了结构证据，表明SV40病毒被阻止靠近最有可能的出口位点，即核孔复合体。从这些图像可以得出结论，附着在核孔复合体上的纤维阻止了SV40颗粒从受感染的细胞核中逸出。
相似文献
1
Fibrils attached to the nuclear pore prevent egress of SV40 particles from the infected nucleus.附着在核孔上的纤维状结构阻止了SV40病毒颗粒从被感染的细胞核中逸出。
J Cell Biol. 1976 Sep;70(3):714-9. doi: 10.1083/jcb.70.3.714.
2
Altered nuclear structure during productive and abortive infections with SV40 DNA.
Intervirology. 1979;12(1):57-64. doi: 10.1159/000149069.
3
Membrane fusion as a mechanism of simian virus 40 entry into different cellular compartments.膜融合作为猿猴病毒40进入不同细胞区室的一种机制。
J Virol. 1978 Dec;28(3):936-44. doi: 10.1128/JVI.28.3.936-944.1978.
4
DNA synthesis and multinucleation of mouse cells infected with SV40 in the presence of cytochalasin B.在细胞松弛素B存在的情况下，感染SV40的小鼠细胞的DNA合成与多核化。
J Gen Virol. 1980 Jan;46(1):237-42. doi: 10.1099/0022-1317-46-1-237.
5
In situ study of SV40 virus DNA in lytic infection by mild loosening of nucleoproteins.通过核蛋白轻度解聚对SV40病毒DNA在裂解感染中的原位研究。
J Gen Virol. 1980 Nov;51(Pt 1):15-31. doi: 10.1099/0022-1317-51-1-15.
6
Association with capsid proteins promotes nuclear targeting of simian virus 40 DNA.与衣壳蛋白的结合促进了猿猴病毒40 DNA的核靶向。
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):96-100. doi: 10.1073/pnas.93.1.96.
7
Uncontrolled nuclear division in murine cells abortively transformed by simian virus 40.
Intervirology. 1976;7(3):145-54. doi: 10.1159/000149948.
8
Mechanism of interferon action: further evidence for transcription as the primary site of action in simian virus 40 infection.干扰素作用机制：在猿猴病毒40感染中，转录作为主要作用位点的进一步证据。
J Gen Virol. 1976 Aug;32(2):227-40. doi: 10.1099/0022-1317-32-2-227.
9
Distinct patterns of MCM protein binding in nuclei of S phase and rereplicating SV40-infected monkey kidney cells.S期细胞核以及再次复制的SV40感染的猴肾细胞中MCM蛋白结合的不同模式。
Cytometry A. 2005 Nov;68(1):10-8. doi: 10.1002/cyto.a.20185.
10
Simian virus 40 associates with nuclear superstructures at early times of infection.猿猴病毒40在感染早期与核超结构相关联。
J Virol. 1987 Mar;61(3):748-54. doi: 10.1128/JVI.61.3.748-754.1987.
引用本文的文献
1
ZC3HC1 has functions distinct from TPR and is dispensable for TPR localisation to the nuclear basket.ZC3HC1具有与TPR不同的功能，并且对于TPR定位于核篮并非必需。
Wellcome Open Res. 2025 Apr 11;10:188. doi: 10.12688/wellcomeopenres.23711.1. eCollection 2025.
2
An evolutionarily conserved bimodular domain anchors ZC3HC1 and its yeast homologue Pml39p to the nuclear basket.一个进化上保守的双模块结构域将 ZC3HC1 及其酵母同源物 Pml39p 锚定到核篮上。
Mol Biol Cell. 2023 May 1;34(5):ar40. doi: 10.1091/mbc.E22-09-0402. Epub 2023 Mar 1.
3
ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket, Resident in a State of Reciprocal Dependence with TPR.ZC3HC1 是核篮的一种新型固有成分，与 TPR 处于相互依赖的状态。
Cells. 2021 Jul 30;10(8):1937. doi: 10.3390/cells10081937.
4
Late Maturation Steps Preceding Selective Nuclear Export and Egress of Progeny Parvovirus.子代细小病毒选择性核输出和释放之前的后期成熟步骤。
J Virol. 2016 May 12;90(11):5462-74. doi: 10.1128/JVI.02967-15. Print 2016 Jun 1.
5
Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion.蛋白 Tpr 对于建立核孔相关的异染色质排斥区是必需的。
EMBO J. 2010 May 19;29(10):1659-73. doi: 10.1038/emboj.2010.54. Epub 2010 Apr 20.
6
Release of simian virus 40 virions from epithelial cells is polarized and occurs without cell lysis.猿猴病毒40病毒粒子从上皮细胞中的释放是极化的，且在不发生细胞裂解的情况下发生。
J Virol. 1989 May;63(5):2278-88. doi: 10.1128/JVI.63.5.2278-2288.1989.
7
Nuclear pore complexes. Elimination and reconstruction during mitosis.核孔复合体。有丝分裂期间的消除与重建。
J Cell Biol. 1977 Aug;74(2):492-500. doi: 10.1083/jcb.74.2.492.
8
Membrane fusion as a mechanism of simian virus 40 entry into different cellular compartments.膜融合作为猿猴病毒40进入不同细胞区室的一种机制。
J Virol. 1978 Dec;28(3):936-44. doi: 10.1128/JVI.28.3.936-944.1978.
本文引用的文献
1
An electron microscope study of the development of SV40 virus.猴空泡病毒40型（SV40）病毒发育的电子显微镜研究
J Cell Biol. 1963 May;17(2):423-41. doi: 10.1083/jcb.17.2.423.
2
Early events in the interaction of adenoviruses with HeLa cells. I. Penetration of type 5 and intracellular release of the DNA genome.腺病毒与HeLa细胞相互作用的早期事件。I. 5型腺病毒的穿透及DNA基因组的细胞内释放
Virology. 1970 Mar;40(3):462-77. doi: 10.1016/0042-6822(70)90189-3.
3
Formation and distribution of nuclear pore complexes in interphase.核孔复合体在间期的形成与分布。
J Cell Biol. 1971 Nov;51(21):405-18. doi: 10.1083/jcb.51.2.405.
4
On the octagonality of the nuclear pore complex.关于核孔复合体的八角形结构
J Cell Biol. 1971 Nov;51(21):558-63. doi: 10.1083/jcb.51.2.558.
5
Procedure for embedding in situ selected cells cultured in vitro.体外培养的原位选择细胞的包埋程序。
J Cell Biol. 1967 Oct;35(1):279-83. doi: 10.1083/jcb.35.1.279.
6
On the attachment of the nuclear pore complex.关于核孔复合体的附着。
J Cell Biol. 1974 Sep;62(3):746-54. doi: 10.1083/jcb.62.3.746.
7
Structure, biochemistry, and functions of the nuclear envelope.核膜的结构、生物化学及功能
Int Rev Cytol. 1974;Suppl 4:71-236.
8
Structure of the nuclear pore complex in mammalian cells. Two annular components.
Exp Cell Res. 1974 Jul;87(1):195-206. doi: 10.1016/0014-4827(74)90542-4.
9
Heterogeneity of simian virus 40 populations: virus particles containing one or two virus DNA molecules?猿猴病毒40群体的异质性：病毒颗粒含有一个还是两个病毒DNA分子？
J Gen Virol. 1974 Jan;22(1):55-71. doi: 10.1099/0022-1317-22-1-55.
10
Enancement of uptake of Simian virus 40 by nuclei of permissive cells.允许性细胞的细胞核对猴病毒40摄取的增强作用。
Proc Soc Exp Biol Med. 1973 Dec;144(3):802-7. doi: 10.3181/00379727-144-37686.
Zotero 插件