附着在核孔上的纤维状结构阻止了SV40病毒颗粒从被感染的细胞核中逸出。
Fibrils attached to the nuclear pore prevent egress of SV40 particles from the infected nucleus.
作者信息
Maul G G
出版信息
J Cell Biol. 1976 Sep;70(3):714-9. doi: 10.1083/jcb.70.3.714.
Abstract
SV40 particles can apparently enter the nucleus intact. However, they do not leave the nucleus despite the high concentration present during the productive phase. We found structural evidence that SV40 virus is prevented from approaching the most likely site of exit, the nuclear pore complex. From these images, it is concluded that the fibrils attached to the nuclear pore complex prevent egress of SV40 particles from the infected nucleus.
摘要
SV40病毒颗粒显然能够完整地进入细胞核。然而，尽管在增殖阶段存在高浓度的病毒颗粒，它们却无法离开细胞核。我们发现了结构证据，表明SV40病毒被阻止靠近最有可能的出口位点，即核孔复合体。从这些图像可以得出结论，附着在核孔复合体上的纤维阻止了SV40颗粒从受感染的细胞核中逸出。
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