Sighinolfi M C, Micali S, De Stefani S, Saredi G, Mofferdin A, Grande M, Bianchi G
Department of Urology, University of Modena and Reggio, via del pozzo 71, Modena, Emilia, 41100, Italy.
Surg Endosc. 2008 May;22(5):1339-41. doi: 10.1007/s00464-008-9766-6. Epub 2008 Feb 13.
Extracorporeal shock wave lithotripsy (ESWL) represents noninvasive management of urolithiasis. Since the first HM3 model, technological progress has improved the efficacy and safety of this treatment. The current study aimed to evaluate the role of ESWL as a first-line emergency therapy of renal colic due to ureteral stone with impaired renal function.
This prospective study enrolled all the patients admitted from the emergency room with acute renal colic meeting the following criteria: serum creatinine level ranging from 1.5 to 2.5 mg/dl, hydronephrosis, ureteral stones 6 to 15 mm in size, body mass index less than 30, normal renal function at baseline, and no evidence of urinary tract infection. The patients were submitted to a single-session emergency treatment using Dornier Litothripter S. Follow-up assessment, performed at 24 and 72 h, included radiologic and ultrasound examinations with renal function serum assessment. The end points were a decrease in creatinine level and a stone-free condition.
A total of 40 patients were eligible for the study. The mean creatinine level at admission was 1.93 +/- 0.26 mg/dl. After the treatment, renal function recovery occurred for 34 subjects (85%), with a significant global decrease in creatinine levels (p = 0.00). The global stone-free rate 72 h after SWL was 67.5% (27/40). The patients with residual fragments were managed using re-SWL (n = 7) and endoscopic technique (n = 6).
Emergency SWL represents an effective tool in the treatment of ureteral stones with hydronephrosis and slight renal impairment. Although complete stone clearance after one treatment still remains a difficult target, the actual role of SWL in the management of acute obstruction is to obtain ureteral canalization and renal function recovery.
体外冲击波碎石术(ESWL)是尿石症的非侵入性治疗方法。自第一代HM3型号以来,技术进步提高了该治疗方法的有效性和安全性。本研究旨在评估ESWL作为肾功能受损的输尿管结石所致肾绞痛一线急诊治疗方法的作用。
本前瞻性研究纳入了所有从急诊室收治的符合以下标准的急性肾绞痛患者:血清肌酐水平为1.5至2.5mg/dl、肾积水、输尿管结石大小为6至15mm、体重指数小于30、基线肾功能正常且无尿路感染证据。患者接受使用多尼尔Litothripter S进行的单次急诊治疗。在24小时和72小时进行的随访评估包括影像学和超声检查以及肾功能血清评估。终点指标为肌酐水平降低和结石清除情况。
共有40例患者符合研究条件。入院时的平均肌酐水平为1.93±0.26mg/dl。治疗后,34例患者(85%)肾功能恢复,肌酐水平显著总体下降(p = 0.00)。SWL术后72小时的总体结石清除率为67.5%(27/40)。残留碎片的患者采用再次SWL(n = 7)和内镜技术(n = 6)进行处理。
急诊SWL是治疗伴有肾积水和轻度肾功能损害的输尿管结石的有效工具。尽管一次治疗后完全清除结石仍然是一个难以实现的目标,但SWL在急性梗阻治疗中的实际作用是实现输尿管疏通和肾功能恢复。