Bianchi Cristina, Penno Giuseppe, Daniele Giuseppe, Benzi Luca, Del Prato Stefano, Miccoli Roberto
Department of Endocrinology and Metabolism, University of Pisa, Ospedale Cisanello, Pisa, Italy.
Intern Emerg Med. 2008 Jun;3(2):87-98. doi: 10.1007/s11739-008-0122-6. Epub 2008 Feb 13.
The prevalence of metabolic syndrome (MS) is increasing all over the world and its incidence is expected to rise in the next years. Although genetic predisposition appears to play an important role in the regulation of metabolic parameters and in particular of body weight, the rapid increase in the prevalence of obesity and MS suggests that ecological factors (social, economic, cultural and physical environment) are promoting those conditions in susceptible individuals. People with MS are at increased risk of type 2 diabetes and cardiovascular disease and therefore they represent a priority target for preventive strategies. Life-style modifications based on healthy diet and increased physical activity are an effective preventing and therapeutic approach. Unfortunately, implementation of life-style modification and maintenance of effects is a difficult task both at personal and social level, thus drug therapy can be taken into account.
代谢综合征（MS）在全球范围内的患病率正在上升，预计在未来几年其发病率还会增加。尽管遗传易感性似乎在代谢参数尤其是体重的调节中发挥重要作用，但肥胖和MS患病率的迅速上升表明，生态因素（社会、经济、文化和物理环境）正在促使易感个体出现这些情况。患有MS的人患2型糖尿病和心血管疾病的风险增加，因此他们是预防策略的优先目标人群。基于健康饮食和增加体育活动的生活方式改变是一种有效的预防和治疗方法。不幸的是，在个人和社会层面实施生活方式改变并维持效果都是一项艰巨的任务，因此可以考虑药物治疗。
