Ressel Volker, Wilke Marko, Lidzba Karen, Lutzenberger Werner, Krägeloh-Mann Ingeborg
Department of Pediatric Neurology and Developmental Medicine, Children's Hospital, University of Tübingen, Hoppe-Seyler-Str. 1, Tübingen 72076, Germany.
Brain Lang. 2008 Sep;106(3):167-76. doi: 10.1016/j.bandl.2008.01.004. Epub 2008 Feb 14.
Previous functional magnetic resonance imaging (fMRI) studies investigating hemispheric dominance for language have shown that hemispheric specialization increases with age. We employed magnetoencephalography (MEG) to investigate these effects as a function of normal development. In sum, 22 healthy children aged 7-16 years were investigated using two language tasks: a verb-generation (VG) task and a vowel-identification (VI) task. Significant hemispheric differences were found for both tasks in cerebral language areas using oscillatory MEG spectral analyses, confirming the MEG's ability to detect hemispheric specialization for language in children. Additionally, a significant increase of this lateralization as a function of age was observed for both tasks. As performance in the VI task showed no correlation with age, this increase seems to be unrelated to performance. These results confirm an increase in hemispheric specialization as a function of normal brain maturation.
先前研究语言半球优势的功能磁共振成像（fMRI）研究表明，半球特化会随着年龄增长而增强。我们采用脑磁图（MEG）来研究这些效应与正常发育之间的关系。总计，我们使用两项语言任务对22名7至16岁的健康儿童进行了研究：动词生成（VG）任务和元音识别（VI）任务。使用振荡MEG频谱分析在大脑语言区域中发现了两项任务均存在显著的半球差异，证实了MEG检测儿童语言半球特化的能力。此外，两项任务均观察到这种偏侧化随年龄增长而显著增加。由于VI任务的表现与年龄无关，这种增加似乎与表现无关。这些结果证实了半球特化会随着正常大脑成熟而增加。
